The pattern-evoked electroretinogram (PERG): Age-related alterations and changes in glaucoma |
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Authors: | Matthias Korth Folkert Horn Brigitte Storck Jost Jonas |
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Affiliation: | 1. Augenklinik der Universit?t, Schwabachanlage 6, D-8520, Erlangen, Federal Republic of Germany
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Abstract: | Pattern-onset electroretinograms (PERGs) were studied in 147 normal subjects of different ages (14-79 years) and in 110 eyes of 65 patients with glaucoma or ocular hypertension. The responses showed an increase (P less than 0.001) in peak latency with increasing age and a decrease (P less than 0.001) in amplitude which approximately parallels the loss of ganglion cells estimated by other authors. Many glaucoma eyes showed a loss of the normally present spatial tuning. In the age group above 50 years 50% of the onset responses were significantly diminished and the peak latencies were not significantly different. A negative correlation (P less than 0.001) was found between the size of the PERG and the cup/disc ratio and a positive correlation (P less than 0.001) with the area of the neuroretinal rim of the optic disc. The PERG decreased (P less than 0.01) with increasing visual field losses. |
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