43例2型糖尿病患者骨密度和骨代谢的研究

目的 探讨2型糖尿病与骨质疏松症的相关因素及发生机制。方法 2型糖尿病患者43例和正常对照43例，采用单光子吸收法测定尺、桡骨骨密度（BMD），以酶联免疫法分别测定空腹血清骨钙素（BGP）及晨尿中脱氧吡啶啉（DPD）值。结果 2型糖尿病组的BMD低于正常对照组，BGP和DPD高于正常对照组。两组比较差异有非常显著性（P〈0．01）。结论 2型糖尿病患者骨形成减少，骨吸收增加，骨质疏松症发生率高。及早对糖尿病性骨质疏松进行防治有重要意义。

Observation on the bone density and bone metabolism of 43 patients with type 2 diabetes mellitus

Objective To discuss the factors associated with osteoporosis in patients with type 2 diabetes mellitus and pathogenesis. Methods 43 patients with type 2 diabetes mellitus including 23 males and 20 females and healthy control inclduing 21 males and 22 females were selected. Single photon absorption was ued to determine the bone mineral density(BMD)of the elbow bone and radial bone. ELISA was used to determine serum osteocalcin(BGP),urine deoxypyridinoline(DPD). Results The BMD of type 2 diabetes mellitus patients are lower than normal control group,The BGP and DPD in the diabetes group were significantly higher than the normal controls (P<0.01). Conclusion Bone formation in type 2 diabetes mellitus patients is decreased and bone absorption is increased. The incidence of osteoporosis in type 2 diabetes mellitus patients is high. It is of great significance to prevent and cure the osteoporosis in patients with type 2 diabetes mellitus early.