| 胃癌与遗传 |
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| 引用本文： | 胡胜,宋启斌. 胃癌与遗传[J]. 中国肿瘤, 2004, 13(12): 790-793 |
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| 作者姓名： | 胡胜 宋启斌 |
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| 作者单位： | 湖北省肿瘤医院,湖北,武汉,430079 |
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| 摘 要： | 胃癌的遗传分两种形式,一种为家族性遗传模式(即强易感性),另一种为人群基础的遗传模式(即弱易感性).胃癌发生与癌基因激活和肿瘤抑制基因失活有关,但并非是两者的简单综合体.胃癌转移和预后也明显受患者遗传背景的影响,如E-cadherin、基质金属蛋白酶等.胃癌与遗传(基因)学研究是一个系统的、全面的过程,单个基因、单个通路难以解释癌症复杂的生物学行为.
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| 关 键 词： | 胃肿瘤 遗传 基因 |
| 文章编号： | 1004-0242(2004)12-0790-04 |
Gastric Cancer and Genetics |
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| HU Sheng,SONG Qi-bin. Gastric Cancer and Genetics[J]. CHINA CANCER, 2004, 13(12): 790-793 |
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| Authors: | HU Sheng SONG Qi-bin |
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| Abstract: | The genetics of gastric cancer commonly has two types:familial pattern (considered as strong susceptibility);and population-based pattern (considered as weak susceptibility).Development of gastric carcinoma is related to activation of oncogene and inhibition of tumor suppressive gene (TSG),however,it is not a simple complex of oncogene and TSG.Metastasis and prognosis of gastric cancer also are influenced by genetic factors, such as E-cadherin,matrix metalloproteinases and so on.The relationship between gastric cancer and genetics is a complicated and comprehensive system.The mechanism is not underlain in single gene or pathway. |
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| Keywords: | gastric neoplasms genetics gene |
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