蒲黄消炎颗粒急性毒性试验

目的:评价蒲黄消炎颗粒的急性毒性,为畜用临床剂量的设计提供依据。方法:蒲黄消炎颗粒按原生药4 g/mL的浓度及40 mL/kg的给药容量,24 h内给昆明种小鼠灌胃1次,连续观察14 d内小鼠的体重,毒性反应及死亡情况。结果:给药组和对照组小鼠在第1、7、14天的体重并无差异;小鼠无死亡,也无明显中毒反应,测得蒲黄消炎颗粒最大耐受量(MTD)为原生药160 g/kg(成人临床拟用量的333倍)。结论:蒲黄消炎颗粒在临床常用剂量下是安全的。

Study of acute toxicity of puhuang antiphlogosis granule

Objective:To evaluate the acute toxicity of Puhuang antiphlogosis granule,for veterinary clinical doses of designed.Methods: Mice were administered with fluid extract of Puhuang antiphlogosis granule for once per day,consecutively observing the body weight,toxic reaction and death of mice during 14 days.Results: There was no significant difference between the body weight of mice in the group of fluid extract and control(P>0.05);the maximum tolerated dose(MTD) of Puhuang antiphlogosis granule on mice is 160.0 g/kg(333 times of clinical adult daily dose).Conclusion: Puhuang antiphlogosis granule is safe in the usual clinical dose.