| 栀子提取物京尼平苷和西红花苷利胆作用的研究 |
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| 引用本文： | 朱振家,钱之玉,陆莉华,任小梅. 栀子提取物京尼平苷和西红花苷利胆作用的研究[J]. 中草药, 1999, 30(11): 841-843 |
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| 作者姓名： | 朱振家 钱之玉 陆莉华 任小梅 |
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| 作者单位： | 中国药科大学药理学教研室,南京,210009 |
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| 摘 要： | 采用测定大鼠胆汁分泌量的实验方法，观察栀子提取物京尼平苷和西红花苷十二指肠给药后的利胆作用。结果显示西红花苷５０和１００ｍｇ／ｋｇ剂量均不增加大鼠的胆汁流量，而京尼平苷５０和１００ｍｇ／ｋｇ剂量均可显著增加大鼠胆汁流量，降低胆汁内胆固醇含量，增加胆汁内ＨＣＯ＾－３浓度，但对胆汁酸，胆红素，「Ｃａ＾２＋」含量无显著影响。
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| 关 键 词： | 京尼平苷 西红花苷 利胆 栀子提取物 |
| 收稿时间： | 1999-06-11 |
| 修稿时间： | 1999-06-11 |
Studies of Geniposide and Crocins from Cape Jasmine(Gardenia jasminoides) on the Biliary Secretion in Rat |
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| Zhu Zhenji,Qian Zhiyu,Lu Lihua. Studies of Geniposide and Crocins from Cape Jasmine(Gardenia jasminoides) on the Biliary Secretion in Rat[J]. Chinese Traditional and Herbal Drugs, 1999, 30(11): 841-843 |
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| Authors: | Zhu Zhenji Qian Zhiyu Lu Lihua |
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| Affiliation: | Department of Pharmacology, China Pharmaceutical University, Nanjing 210009;Department of Pharmacology, China Pharmaceutical University, Nanjing 210009;Department of Pharmacology, China Pharmaceutical University, Nanjing 210009;Department of Pharmacology, China Pharmaceutical University, Nanjing 210009 |
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| Abstract: | Effects of geniposide and crocins,the two extracts from Gardenia jasminoides Ellis, on the biliary secretion in rat were investigated. It was observed that, at the doses of 50mg/kg and 100mg/kg, geniposide could significantly increase the binary secretion after intraduodenal administration, while crocins showed no effect. On the other hand, geniposide can markedly decrease the content of cholesterol and elevate HCO_3~- concentration in bile, but without effect on the level of bilirubin, bile acid and Ca~(2 ). The results show that geniposide is the main choleretic principle in Gardenia jasminoides Ellis. |
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| Keywords: | geniposide crocin choleretics bile contents |
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