| 阿托伐他汀减少冠脉介入治疗引起心肌损伤的研究 |
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| 引用本文： | 曲春雁,唐爱萍,王军志. 阿托伐他汀减少冠脉介入治疗引起心肌损伤的研究[J]. 实用预防医学, 2007, 14(2): 497-498 |
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| 作者姓名： | 曲春雁 唐爱萍 王军志 |
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| 作者单位： | 1. 青岛市崂山区妇幼保健院内科,山东,青岛,266101
2. 青岛市海慈医疗集团心内科 |
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| 摘 要： | 目的研究他汀类药物能否减少冠脉介入治疗(PCI)带来的心肌坏死。方法在PCI术前7 d随机给予阿托伐他汀40 mg/d或者安慰剂口服,在术前和术后8 h、24 h检测CK-MB、肌钙蛋白Ⅰ型和肌红蛋白。结果PCI术后心肌损伤的标记物升高,在阿托伐他汀组升高的人数明显低于安慰剂组,PCI术后酶学峰值升高在阿托伐他汀组比安慰剂组减低。结论在PCI术前7 d给予阿托伐他汀40 mg/d能明显减少心肌损伤。
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| 关 键 词： | 冠状动脉 介入治疗 心肌损伤 阿托伐他汀 |
| 文章编号： | 1006-3110（2007）02-0497-02 |
| 收稿时间： | 2006-12-23 |
| 修稿时间： | 2006-12-23 |
Research of Atorvastation in Reducing Myocardial Injure After Coronary Arterial Intervention |
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| QU Chun-yan,TANG Ai-ping,WANG Jun-zhi. Research of Atorvastation in Reducing Myocardial Injure After Coronary Arterial Intervention[J]. Practical Preventive Medicine, 2007, 14(2): 497-498 |
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| Authors: | QU Chun-yan TANG Ai-ping WANG Jun-zhi |
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| Affiliation: | Women and Children Health Care Hospital of Laoshan District, Qingdao 266101, Shandong, China |
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| Abstract: | Objective To study the effect of atorvastation in reduction of myocardial injury during percutaneous coronary intervention(PCI).Methods The two treatment groups were received atorvastation 40mg daily or placebo in 7 successive days before PCI,and CK-MB,cardiac troponin and myoglobin were monitored before and 4 and 24 hours after the procedure.Results The myocardial injury markers were elevated after PCI,however,both the number of ascended patients and the ascended peak value of enzyme in the atrovastatin treatment group were signigicantly lower than those of the placebo group.Conclusion Administering 40mg atorvastation dialy in 7 successive days before PCI can significantly reduce the myocardial injury. |
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| Keywords: | Coronary artery PCI Myocardial injury Atorvastation |
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