Differential immunohistochemical detection of cytokeratins and vimentin in the surgically removed human endolymphatic duct and sac |
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Authors: | L. J. J. M. Bauwens J. C. M. J. De Groot F. C. S. Ramaekers F. Linthicum J. E. Veldman E. H. Huizing |
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Affiliation: | (1) Department of Otorhinolaryngology, University Hospital Utrecht, Utrecht, The Netherlands;(2) Department of Molecular Cell Biology, University of Limburg, Maastricht, The Netherlands;(3) The House Ear Institute, Los Angeles, California, USA;(4) Laboratory for Histophysiology and Experimental Pathology, Department of Otorhinolaryngology, University Hospital Utrecht, Heidelberglaan 100, NL-3584 CX Utrecht, The Netherlands |
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Abstract: | Summary Immunohistochemical detection of intermediate filament proteins and different subgroups of cytokeratins (Cks) was used to characterize the epithelium of the surgically removed adult human endolymphatic duct (ED) and sac (ES). The epithelium of the ED and ES demonstrated immunostaining for Cks 7, 8, 14, 17, 18 and 19, a pattern typical of so-called complex or mixed epithelia. This is a remarkable finding, since this pattern differs strikingly from previously reported data on the adult human cochlea and vestibular labyrinth that demonstrated a Ck pattern typical of simple (or single-layered) epithelia. Furthermore, the epithelium of the ED and ES demonstrated co-expression of Cks and vimentin. The present data indicate that the epithelium of the ED and ES exhibits another type of epithelial differentiation and demonstrates a higher degree of complexity than the other epithelia in the adult human inner ear. |
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Keywords: | Human endolymphatic duct and sac Intermediate filaments Cytokeratins Immunohistochemistry |
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