| 琥珀酸美托洛尔缓释片对冠心病无症状心肌缺血及心率变异性的影响 |
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| 引用本文： | 王莹,贾连旺. 琥珀酸美托洛尔缓释片对冠心病无症状心肌缺血及心率变异性的影响[J]. 海峡药学, 2008, 20(11): 69-72 |
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| 作者姓名： | 王莹 贾连旺 |
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| 作者单位： | 浙江省金华市中心医院,金华,321000;浙江省金华市中心医院,金华,321000 |
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| 摘 要： | 目的 探讨琥珀酸美托洛尔缓释片对冠心病无症状心肌缺血及心率变异性(HRV)的影响.方法 随机将70例冠心病心肌缺血患者分为2组,其中35例在常规药物阿司匹林、普伐他汀基础上加用美托洛尔缓释片治疗为美托洛尔缓释片(A)组,其余35例应用阿司匹林、普伐他汀联合硝酸异山梨酯治疗为硝酸酯(B)组.治疗前后进行动态心电图检测,对缺血及HRV的相关指标作对比观察.结果 治疗8周后,有症状的ST段压低次数及其持续时间与无症状的ST段压低及其持续时间,A与B两组均有明显减少及缩短,与治疗前比较,差异均有显著性(P＜0.01与＜0.05),2组间疗效比较,A组明显优于B组(P＜0.01).同时,A组HRV指标(SDNN、SDANN、SDNNindex)亦明显改善(P均＜0.01),但B组治疗前后HRV各指标差异不显著(P＞0.05).美托洛尔缓释片治疗期间,患者无严重不良反应.结论 美托洛尔缓释片不仅对冠心病无症状心肌缺血有显著疗效,且能改善HRV.
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| 关 键 词： | 琥珀酸美托洛尔缓释片 无症状心肌缺血 冠心病 心率变异性 |
Therapeufic efficacy of metoprolol succinate sustained-release tablets on silent myocardial ischemia and heart rate variability with coronary heart disease |
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| WANG Ying,JIA Lian-wang. Therapeufic efficacy of metoprolol succinate sustained-release tablets on silent myocardial ischemia and heart rate variability with coronary heart disease[J]. Strait Pharmaceutical Journal, 2008, 20(11): 69-72 |
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| Authors: | WANG Ying JIA Lian-wang |
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| Affiliation: | WANG Ying,JIA Lian-wang(Zhejiang Jinhua central hospital,Jinhua 321000 China) |
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| Abstract: | OBJECTIVE To explore the therapeutic efficacy of metoprolol succinate sustained-release tablets(metoprolol-SR)on silent myocardial ischemic(SMl)and heart rate variability(HRV)with coronary heart disease.METHODS Seventy cases of coronary heart disease were randomly divided into group A(35 cases)and B(35 cases).The group B was treated with aspirin,pravastatin and sorbitrate,group A was treated with metoprolol-SR based on the aspirin and pravastatin.The changes of SMI and HRV were observed by Dynamic electroca... |
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| Keywords: | Metoprolol succinate sustained-release tablets Silent myocardial ischemia Cornary heart disease Heart rate variability |
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