| 青心酮对豚鼠离体气管条张力的影响及其机制 |
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| 引用本文： | 叶笃筠,吴萍,黄云峰,洪志刚,熊宗斌,余尚斌.青心酮对豚鼠离体气管条张力的影响及其机制[J].医学教育探索,2000(6):438-440. |
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| 作者姓名： | 叶笃筠 吴萍 黄云峰 洪志刚 熊宗斌 余尚斌 |
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| 作者单位： | 同济医科大学病理生理教研室!武汉430030 |
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| 摘 要： | 采用气管条浴槽实验方法，观察青心酮对离体豚鼠气管螺旋条张力的影响。结果发现：ＤＨＡＰ明显松驰豚鼠的离体气管平滑肌；抑制由乙酰胆碱、组胺和氯化钾所了体豚鼠气管平滑肌的收缩反应，对５－羟色胺诱发的由内钙释放引起的Ⅰ相收缩和外钙内流所致的Ⅱ相气管平滑肌收缩均有一定的抑制作用。
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| 关 键 词： | 青心酮 张力 肺疾病 呼吸道疾病 豚鼠 |
Effect of 3,4-Dihydroxyacetophenone on Isolated Guinea-Pig Trachea and Its Mechanism of Action |
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| Ye Duyun,Wu Ping,Huang Yunfeng,Hong Zhigang,Xiong Zongbin,Yu Shangbin.Effect of 3,4-Dihydroxyacetophenone on Isolated Guinea-Pig Trachea and Its Mechanism of Action[J].Researches in Medical Education,2000(6):438-440. |
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| Authors: | Ye Duyun Wu Ping Huang Yunfeng Hong Zhigang Xiong Zongbin Yu Shangbin |
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| Institution: | Wuhan 430030 |
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| Abstract: | The Effects of 3,4 dihydroxyacetophenone (DHAP) on the tension of isolated guinea pig trachea spirals were studied by tension recording method It was found that DHAP relaxed the basal tension and markedly depressed the contractile response induced by the spasmogens (Ach, histamin, KCl, 5 HT) in a concentration dependent manner But indomethacin, a cyclooxygenase inhibitor, showed no influence on the relaxant effect of DHAP against the contraction of the spirals caused by Ach DHAP could abolish the contraction induced by 5 HT both in phase 1 (release of intracellular calcium) and phase 2 (entrance of extracellular calcium) These results suggested that the relaxant effect of DHAP on isolated guinea pig trachea spirals may be resulted from a decreased concentration of intracellular calcium |
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| Keywords: | dihydroxyacetophenone trachea smooth muscle tension |
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