麝香保心丸对心肌一氧化氮合酶及左室功能的影响

观察了麝香保心丸对心肌组织内皮型一氧化氮合酶（ｅＮＯＳ）的表达及左室功能的影响，在大鼠心梗模型上治疗组给予麝香保心丸３３ｍｇ／ｄ２或６周，用心导管测定心脏功能，免疫组织化学地测定心肌ｅＮＯＳ水平，结果表明，麝香保心丸可同时增加心肌ｅＮＯＳ的表达水平，改善心梗后左室收缩及舒张功能。

Effects of Heart-protecting Musk Pill on the Expression of Myocardial Endothelial Nitric Oxide Synthase and Left Ventricular Function after Myocardial Infarction in Rats

Effects of heart protecting musk pill (HMP), a traditional medical preparation for the treatment of myocardial infarction, on the expression of myocardial endothelial NO synthase (eNOS) and left ventricular function of acute myocardial infarcition (AMI) rat model were studied. AMI rat models were prepared by coronary artery ligation and randomized into 4 groups: Two groups of AMi-2 and AMI-6 were kept as controls, and the other two, were treated with HMP 33mg/d by intubation for 2 weeks (HMP-2) or 6 weeks (HMP-6). Cardiac functions (LVESP, LVEDP, dp/dtmax, dp/dtmin) were measured at the end of 2nd and sixth week of treatment with left ventricular catheter insertion. The level of myocardial eNOS were measured by immunohistochemical staining and image analysis. Results showed that the 2 HMP treated groups resulted in an increase of expression of myocardial eNOS (P<0.05) and an improved systolic, and diastolic functions of left ventricular at the end of 2nd and sixth week of treatment as compared with the control (P< 0.05). It may be concluded that HMP can increase the level of myocardial eNOS and improve cardiac functions after myocardial infarction at the same time.