海带多糖对糖尿病小鼠血糖的调节作用

目的 :　研究海带多糖 ( Laminarina Japonica Polysaccharides LJPS)对四氧嘧啶所致糖尿病小鼠血糖的调节作用。方法 :　从小鼠尾静脉注射 55mg/kg bw剂量的四氧嘧啶造成糖尿病小鼠模型 ,按 1 2 5、2 50、50 0 mg/kg bw剂量的海带多糖连续灌胃糖尿病小鼠 3w后 ,测定空腹血糖、尿素氮、血清钙、血清胰岛素含量等指标并做胰腺病理检查。结果 :　海带多糖能明显降低糖尿病小鼠血糖和尿素氮 ,其血糖降低率分别为 34.96% ,2 0 .70 % ,2 6.82 % ,增加糖尿病小鼠的血清钙和血清胰岛素含量 ,对四氧嘧啶所致的胰岛损伤具有明显的恢复作用。结论 :　海带多糖对糖尿病小鼠有降血糖及保护胰岛细胞的功能。

THE HYPOGLYCEMIC EFFECT OF LAMINARINA JAPONICA POLYSACCHARIDES IN DIABETIC MICE

Objective: To explore the effect of Laminarina Japonica Polysaccharides (LJPS) on blood glucose in diabetes mice.Methods: Effect of LJPS on alloxan inducing diabetes mellitus model was investigated by applying different doses(125,250 and 500mg/kg bw).Results: The doses of LJPS were able to lower blood glucose level by 34.96%,20.70% and 26.82% respectively. They also decreased BUN level, enhanced liver glycogen, calcium in serum and insulin concentration. LJPS could restore the injury of alloxan induced pancreas islet significantly by histopathological findingConclusion: The results show that LJPS is an active component in protecting against alloxan induced pancreas injury and mediating the blood glucose level.