Successful treatment of lichen myxoedematosus with PUVA photochemotherapy |
| |
Authors: | Adachi Y Iba S Horio T |
| |
Affiliation: | Department of Dermatology, Kansai Medical University, Moriguchi-city, Osaka, Japan. |
| |
Abstract: | Lichen myxoedematosus is an unusual disorder of unknown etiology and pathogenesis. Although several treatments have reportedly been tried, therapeutic efficacies are variable and unsatisfactory. A patient with severe skin changes of this disease was successfully treated with PUVA photochemotherapy. PUVA therapy was carried out using 30 mg of 8-methoxypsoralen orally, and subsequent exposure to UVA starting at 4 J/cm2. The eruption disappeared almost completely after 35 treatments at a cumulative dose of 202 J/cm2. Histologically, mucin deposition was greatly diminished after the therapy. The photochemotherapy may exert its effect directly by inhibiting proliferation of fibroblasts and synthesis of mucopolysaccharides, and also indirectly by immunomodulating action. |
| |
Keywords: | lichen myxoedematosus PUVA photochemotherapy fibroblast mucopolysaccharide |
本文献已被 PubMed 等数据库收录! |
|