老年抑郁症影像学研究进展

老年抑郁症(late-life depression,LLD)作为一种异质性综合征,是临床常见的精神疾病。目前,关于老年抑郁症的病理生理机制尚不明确,以往诸多研究往往强调其发生与血管损害、神经炎性等改变相关。随着影像技术的发展,越来越多的神经影像学研究表明,老年抑郁症的发生机制与脑结构、脑功能及脑代谢改变关系密切。影像技术作为一种无创的检查方法日臻成熟,与当前广泛应用的临床诊断方法相比,它能够提供更直观的可视化证据,且可以减少因主观因素对结果造成的误差。现影像学已广泛应用于老年抑郁症的神经生物学机制研究中,这为老年抑郁症的诊治及评估预后提供了新的思路及治疗方法。作者对影像学在老年抑郁症中的研究进行综述。

Advances in imaging studies of senile depression

Late-life depression(LLD),as a heterogeneous syndrome,is a common clinical psychiatric disorder.At present,the pathophysiological mechanism of senile depression is not clear,and many previous studies often emphasize that its occurrence is related to vascular damage,nerve inflammation and other changes.With the development of imaging technology,more and more neuroimaging studies have shown that the pathogenesis of senile depression is closely related to changes in brain structure,brain function and brain metabolism.As a non-invasive examination method,imaging technology is becoming more and more mature.Compared with the widely used clinical diagnosis methods,it can provide more visual evidence and reduce the error caused by subjective factors.Now,imaging has been widely used in the study of neurobiological mechanism of senile depression,which provides new ideas and treatment methods for the diagnosis,treatment and prognosis evaluation of senile depression.This article will review the study of imaging in senile depression.