COPD不同HRCT表型患者血清中性粒细胞弹性蛋白酶、总抗氧化能力比较 |
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作者姓名: | 陈红波 陈丽萍 金永明 王丽娜 朱丽蕊 沈荣琼 |
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作者单位: | 安宁市人民医院呼吸与危重症医学科,云南 昆明 653100 |
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基金项目: | 昆明市卫计委科研基金资助项目 |
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摘 要: | 目的 探讨中性粒细胞弹性蛋白酶(neutrophil elastase,NE)、总抗氧化能力(total antioxidative capability,T-AOC)在慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)高分辨率CT(high-resolution computed tomography,HRCT)不同表型中的差异。 方法 对78例门诊COPD患者,采用HRCT将COPD患者分为A表型、M表型和E表型,分别测定三组患者NE及T-AOC。 结果 COPD患者M表型的血清NE含量高于对照组、A表型、E表型(P < 0.05);E表型的血清NE含量高于对照组、A表型( P < 0.05);三组及对照组T-AOC差异无统计学意义( P > 0.05);血清NE与FEV1、FEV1%pred呈负相关( P < 0.05),与CAT评分呈正相关( P < 0.05)。 结论 NE在COPD患者不同HRCT表型中的表达上调并与肺功能指标相关,NE可能参与了COPD的气道炎症、气道重构过程,并引起气流阻塞。
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关 键 词: | COPD 表型 HRCT 血清中性粒细胞弹性蛋白酶 总抗氧化能力 |
收稿时间: | 2020-03-26 |
Comparative Study of Neutrophil Elastase and Total Antioxidant Capacity in Serum of COPD Patients with Different HRCT Phenotypes |
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Institution: | Dept.of Respiratory Medicine,Anning people’s Hospital,Kunming Yunnan 653100,China |
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Abstract: | Objective To explore the neutrophil elastase(neutrophil elastase, NE), total antioxidant capacity(total antioxidative capability, T - AOC)in chronic obstructive pulmonary disease(chronic obstructive pulmonary diseases, COPD)high-resolution CT(high-resolution computed tomography, HRCT)in different HRCT phenotypes. Methods HRCT was used for typing 78 patients with out-patient COPD into phenotype A, phenotype M and phenotype E; NE and T-AOC of the three groups of patients were tested. Results The serum NE concentration of phenotype M in COPD patients was higher than that of control group, phenotype A and phenotype E(P < 0.05). The serum NE concentration of phenotype E was higher than that of control group and phenotype A( P < 0.05). There was no significant difference in T-AOC between the three groups and the control group( P > 0.05). The NE in serum was negatively correlated with FEV1 and FEV1% pred.( P < 0.05), and positively correlated with CAT score( P < 0.05). Conclusion The expression of NE in COPD patients with different HRCT phenotypes is up-regulated and correlated with lung function indicators, and NE may be involved in airway inflammation and airway remodeling in COPD and cause airflow obstruction. |
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