| E-cad、MMP-2在子宫腺肌病中的表达及意义 |
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| 引用本文： | 韩雪松,徐琳,普苹,付红梅,单朝萍,董文漪.E-cad、MMP-2在子宫腺肌病中的表达及意义[J].昆明医学院学报,2005,26(4):89-92. |
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| 作者姓名： | 韩雪松 徐琳 普苹 付红梅 单朝萍 董文漪 |
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| 作者单位： | 1. 昆明医学院第一附属医院妇科,昆明,650032
2. 昆明医学院第一附属医院病理科,昆明,650032 |
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| 摘 要： | 目的：研究E-cad、MMP-2在子宫腺肌病中的表达，探讨其表达与子宫腺肌病发生的相关性．方法：应用免疫组化SP染色法检测30例子宫腺肌病在位内膜、异位内膜、16例对照组子宫内膜E-cad、MMP-2的表达．结果：E-cad在子宫腺肌病在位内膜组中的表达显著低于对照组（P〈0．05）；E-cad在子宫腺肌病异位内膜组中的表达显著低于子宫腺肌病在位内膜组（P〈0．01）．MMP-2在子宫腺肌病异位内膜组中的表达显著高于子宫腺肌病在位内膜组及对照组（P〈0．01，P〈0．01）．结论：E-cad、MMP-2的异常表达可能与子宫腺肌病的发生有关．
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| 关 键 词： | 子宫腺肌病 E-cad MMP-2 免疫组化 |
| 文章编号： | 1003-4706(2005)04-0089-04 |
| 收稿时间： | 2005-08-20 |
| 修稿时间： | 2005年8月20日 |
Expression of E - cad and MMP - 2 in Human Adenomyosis and Its Significance |
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| HAN Xue-song,XU Lin,PU Ping,FU Hong-mei,SHAN Zhao-ping,DONG Wen-yi.Expression of E - cad and MMP - 2 in Human Adenomyosis and Its Significance[J].Journal of Kunming Medical College,2005,26(4):89-92. |
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| Authors: | HAN Xue-song XU Lin PU Ping FU Hong-mei SHAN Zhao-ping DONG Wen-yi |
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| Institution: | 1.Dept. of Crynecology; 2. Dept. of Pathology, The 1 st Affiliated Hospital of Kunming Medical College, Kunming 650032, China |
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| Abstract: | Objective: To study the expression of E-cad and MMP-2 in human adenomyosis and to explore the correlation between the expression and pathogenesis of human adenomyosis.Methods: Immunohistochemical S-P method was employed to detect the expression of E-cad and MMP-2 in 30 specimens of ectopic endometrium,eutopic endometrium of adenomyosis and 16 specimens of normal endometrium.Results: The expression of E-cad in ectopic and eutopic endometrium of adenomyosis were significantly lower than those of normal endometrium(P<0.01,P<0.05).The expression of MMP-2 in ectopic endometrium of adenomyosis were significantly higher than those of eutopic endometrium of adenomyosis and normal endometrium(P<0.01,P<0.01).Conclusion: The abnormal expression of E-cad and MMP-2 might be correlated with the pathogenesis of human adenomyosis. |
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| Keywords: | Adenomyosis E - cad MMP- 2 Immunohistochemistry |
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