| 间日疟原虫子孢子免疫BALB/c小鼠的试验研究 |
| |
| 引用本文： | 余文祥,李菊升,李崇珍,余蕾,黄云芝. 间日疟原虫子孢子免疫BALB/c小鼠的试验研究[J]. 中国病原生物学杂志, 1993, 0(3) |
| |
| 作者姓名： | 余文祥 李菊升 李崇珍 余蕾 黄云芝 |
| |
| 作者单位： | 云南省疟疾防治研究所 (思茅665000) |
| |
| 摘 要： | 用间日疟病人血,离体感染中华按蚊,分离子孢子,用10～12万条子孢子/次的量,免疫BALB/c小鼠,抗体效价均达到1:640,取其脾细胞作融合试验,已培养出抗体滴度高、特异性强的抗间日疟原虫子孢子单克隆抗体(McAb)。
|
| 关 键 词： | 间日疟原虫子孢子 免疫 |
STUDIES ON IMMUNIZATION OF BALB/c MICE WITH PLASMODIUM VIVAX SPOROZOITES |
| |
| Yu Wen-Xiang,Li Ju-Sheng,Li Chong-Zhen,Yu Lei,Huang Yun-Zhi Institute of Malaria Prevention and Treatment of Yunnan Province. STUDIES ON IMMUNIZATION OF BALB/c MICE WITH PLASMODIUM VIVAX SPOROZOITES[J]. Journal of Pathogen Biology, 1993, 0(3) |
| |
| Authors: | Yu Wen-Xiang Li Ju-Sheng Li Chong-Zhen Yu Lei Huang Yun-Zhi Institute of Malaria Prevention Treatment of Yunnan Province |
| |
| Affiliation: | Simao 665000 |
| |
| Abstract: | The blood taken from Plasmodium vivax patients was used for membrane-feed- ing An. Sinensis wiedmanns. 15 day later or so,the sporozoites were separated. Each mouse was immunized with 100-120 thousand sporozoites per time according to a certain schedual. All the titers of antibody to sporozoites from immunized mice reached to 1:640. The spleen cells from im- munized mice were fused with SP2/0 cells to obtain the monoclonal antibodies to P. vivax sporo- zoites with high titers and specificity. |
| |
| Keywords: | P. vivax sporozoite immunization mouse monoclonal antibody |
| 本文献已被 CNKI 等数据库收录！ |
|
