水通道蛋白与肿瘤血管新生

肿瘤血管新生对于肿瘤的生长具有重要作用。水通道蛋白在肿瘤组织中常出现表达异常，并且可以促进肿瘤血管的新生及包括肿瘤血管内皮在内的多种细胞的迁移，与此同时，水通道蛋白与肿瘤血管的高通透性有关，这可能是肿瘤组织对水通道蛋白缺失具有较高敏感性的原因。鉴于水通道蛋白对于肿瘤特别是肿瘤血管新生的影响，其抑制剂可能成为新的肿瘤治疗的目标靶点。

Aquaporins and the angiogenesis of tumors

Angiogenesis plays an important role in carcinogenesis.Aquaporins.(AQPs) are anomalously expressed in many types of tumors and induces migration of various cell lines including the tumor vascular endothelia which is crucial in tumor angiogenesis.AQPs are also involved in the high carcinovascular permeability,which is potentially related to tumor's high sensibility to the loss of AQP1.Based on the effects of AQPs on tumor angiogenesis,the AQPs inhibitors can be regarded as novel targets of anti-cancer therapy.