| Institution: | (1) Department of Hand Surgery, University of Heidelberg, Schlierbacher Landstrasse 200, 69118, Heidelberg, Germany;(2) Department of Orthopedic Surgery, University of Heidelberg, Schlierbacher Landstrasse 200, 69118, Heidelberg, Germany;(3) Department of Pediatric Hematology and Oncology, University Children s Hospital Münster, Albert-Schweitzer-Strasse 33, 48149, Münster, Germany;(4) Department of Orthopedic Surgery, University of Vienna, Währinger Gürtel 18-20, 1090, Vienna, Austria;(5) Department of Orthopedic Surgery, University of Münster, Albert-Schweitzer-Strasse 33, 48149, Münster, Germany;(6) University Childrens Hospital, Martinistrasse 52, 20246, Hamburg, Germany |
| Abstract: | Background Osteosarcoma is extremely rare in the hand and forearm. Therefore, only limited data are available for planning treatment or predicting the outcome and prognosis of osteosarcoma in the peripheral upper extremity.Methods Epidemiological, clinical, and histopathologic data were analyzed in 39 patients with osteosarcoma of the forearm or hand who were enrolled in studies of the Cooperative German-Austrian-Swiss Osteosarcoma Study Group from 1977 to December 2000. In patients with high-grade osteosarcoma, the treatment entailed surgical resection in combination with chemotherapy, whereas patients with low-grade osteosarcoma underwent only surgery.Results The 5-year overall survival rate among the 33 patients with high-grade central osteosarcoma of the distal upper extremity was 86.2% ±6.4%. The 5-year event-free survival rate was 65.4%±9.6%. Five of the eight patients with secondary metastases were in remission at the time of analysis. Four patients died of their disease, and two patients died of chemotherapy-related complications. The mean overall survival rate was 88.0%±6.5% in patients treated by wide or radical tumor resection and was 75.0%±21.7% in patients with nonwide margins of resection. Whether amputation or local resection was performed had no significant influence on the prognosis. All six patients whose osteosarcoma was not classified as high-grade central osteosarcoma were in remission at the time of analysis.Conclusions The results demonstrate a remarkably high survival rate for patients with high-grade osteosarcoma of the hand and forearm and confirm that multiagent chemotherapy in combination with wide excision is a highly effective treatment for this malignant tumor.Published by Springer Science+Business Media, Inc. © 2005 The Society of Surgical Oncology, Inc. |
