| P13K／AKT／mTOR信号通路在乳腺癌Her-2治疗耐药中的作用研究进展 |
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| 引用本文： | 马瑞金,杨宇.P13K／AKT／mTOR信号通路在乳腺癌Her-2治疗耐药中的作用研究进展[J].实用肿瘤学杂志,2014(4):360-363. |
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| 作者姓名： | 马瑞金 杨宇 |
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| 作者单位： | 哈尔滨医科大学附属第二医院肿瘤内科,哈尔滨150086 |
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| 摘 要： | Her-2靶向治疗是Her-2过表达乳腺癌治疗的重要组成部分，但Her-2靶向治疗的耐药严重影响了乳腺癌的治疗。研究证实乳腺癌Her-2靶向治疗出现耐药的过程中有P13K／AKT／mTOR信号通路的激活，因此对P13K／AKT／mTOR信号通路及以P13K／AKT／mTOR信号通路为靶点的药物研究对乳腺癌治疗具有重要意义。
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| 关 键 词： | P13K AKT mTOR Her-2 乳腺肿瘤 靶向治疗 |
The research development of PI3K/AKT/mTOR signaling pathway in Her - 2 resistance for the treat- ment of breast cancer |
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| MA Ruijin,YANG Yu.The research development of PI3K/AKT/mTOR signaling pathway in Her - 2 resistance for the treat- ment of breast cancer[J].Journal of Practical Oncology,2014(4):360-363. |
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| Authors: | MA Ruijin YANG Yu |
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| Institution: | Department of Oncology ,The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China |
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| Abstract: | Her -2 targeting therapy is an important part of the treatment for breast cancer with Her -2 overexpression. However, the therapeutic effectiveness is largely influenced by Her - 2 resistance. Previous studies have confirmed that PI3K/AKT/mTOR signaling pathway is activated during the process of drug resistance to Her -2- targeting therapy. Therefore, investigating the PI3K/AKT/mTOR signaling pathway and drugs -targeted pathway are important for the treatment of breast cancer. |
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| Keywords: | PI3 K/AKT/mTOR pathway Her - 2 Breast neoplasms Targeted therapy |
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