三阴性乳腺癌中MMP-9及E－cadherin表达的意义

目的：探讨三阴性乳腺癌（ TNBC）中基质金属蛋白酶-9（ MMP-9）及E-钙粘蛋白（ E-cadherin）表达情况及二者与TNBC临床病理特征的关系，从而分析MMP-9与E-cadherin在TNBC发生发展中的作用。方法应用免疫组化法检测127例TNBC组织中MMP-9和E-cadherin的表达情况。结果 TNBC中MMP-9阳性表达率为53．54％，E-cadherin阳性表达率为32．28％。 MMP-9的表达与肿瘤大小（P＝0．007），组织学分级（P＝0．006），临床分期（P＝0．003），淋巴结转移（P＝0．000）和淋巴管浸润（P＝0．015）相关。 E-cadherin的表达与淋巴结转移（P＝0．016）和淋巴管浸润（P＝0．021）相关。同时统计结果显示二者表达与其他因素无相关性（ P＞0．05）。结论 MMP-9和E-cadherin与TNBC的浸润和转移有关，可能成为TNBC靶向治疗的研究靶点。

Significance of the expression of MMP-9 and E-cadherin in triple negative breast cancer

Objective To investigate the expression of matrixmetalloprotein -9（MMP-9）and E-cad-herin in triple negative breast cancer （ TNBC） and its relationship with the clinicopathologic features of TNBC .To analyze the function of MMP -9 and E-cadherin in TNBC .Methods Immunohistochemical method was used to detect the expression of MMP -9 and E-cadherin in 127 cases of TNBC.Results The MMP-9 positive rate was 53.54%and E-cadherin positive grade was 32.28%in TNBC.Expression of MMP-9 was correlated with tumor size（P=0.007）,histological grade（P=0.006）,TNM stage（P=0.003）,lymph node metastasis（P=0.000）and lymph duct invasive（P=0.000）.Expression of E-cadherin was correlated with lymph node metasta-sis（P=0.016）and lymph duct invasive（P=0.015）.However,they were not correlated with other factors .Con-clusion The expression of MMP -9 and E -cadherin was correlated with invasion and metastasis in TNBC , which could be an important research topic in the future studies .