2型糖尿病并脑梗死患者血清MMP-2、TIMP-1水平变化

目的观察2型糖尿病并脑梗死患者血清基质金属蛋白酶-2（matrix metalloproteinase-2，MMP-2）及其抑制因子基质金属蛋白酶抑制因子-1（tissue inhibitors of matrix metalloproteinase-1，TIMP-1）的水平变化，探讨其在脑梗死发生发展过程中的作用和意义。方法用ELISA法检测48例2型糖尿病并脑梗死患者发病24h，以及35例2型糖尿病非脑梗死患者、29例非糖尿病脑梗死组、39例健康体检者血清MMP-2和TIMP-1的含量。结果2型糖尿病脑梗死患者血清MMP-2、TIMP-1水平显著高于2型糖尿病非脑梗死组、非糖尿病脑梗死组、对照组（P〈0．05）。2型糖尿病脑梗死发病24h的血清MMP-2水平与空腹血糖、糖化血红蛋白（HbAlc）正相关（r=0．296，r=0．339）；2型糖尿病脑梗死发病24h血清TIMP-1水平与空腹血糖呈正相关（r=0．293），与HbA1c呈正相关（r=0．391）。与神经功能缺损程度评分（脑卒中分值）、总胆固醇、甘油三脂均无明显相关性（P〉0．05）。结论2型糖尿病并脑梗死患者血清MMP-2和TIMP-1水平增高且与血糖水平呈正相关，MMP-2和TIMP-1在2型糖尿病脑梗死发病过程中起着重要的作用。

Levels of Serum MMP - 2 and TIMP - 1 in Cerebral Infarction Patients with Type 2 Diabetes Mellitus

Objective To investigate the role and clinical significance of serum matrix metalloproteinase - 2 （MMP - 2） and tissue inhibitors＇or matrix metalloproteinase- 1 （TIMP- 1） levels in cerebral infarction patients with type 2 diabetes mellitus （DM）. Methods Serum MMP - 2 and TIMP - 1 levels were measured in 48 cerebral infarction patients with type 2 diabetes mellitus, 35 type 2 diabetes mellitus patients without cerebral infarction, 29 cerebral infarction patients without DM, and 39 health check - up subjects by ELISA. Results The levels of serum MMP - 2 and TIMP - 1 in cerebral infarction patients with type 2 diabetes mellitus were significantly higher than those of type 2 diabetes mellitus patients without cei＇ebral infarction, cerebral infarction patients without DM, and healthy group （P〈 0.05）. Levels of serum MMP - 2 and TIMP - 1 in cerebral infarction patients with type 2 diabetes mellitus correlated positively with fasting blood sugar （FBS） and HbAlc. No significant correlation was observed between the levels of MMP- 2, TIMP- 1 and score of neurological deficits, total serum cholesterol, and serum glycerol lipid. Conclusions MMP - 2 and TIMP - 1 may contribute the pathologic course in the early stage of cerebral infarction with type 2 DM, and the levels of MM P - 2 and TIMP - 1 correlate positively with the clinical course of the disease.