| 粉防己碱与抗肿瘤药物相互作用对HNE-1细胞周期的影响 |
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| 引用本文： | 王洪鹏,叶琳,王驰,陈鸿雁. 粉防己碱与抗肿瘤药物相互作用对HNE-1细胞周期的影响[J]. 中国中医急症, 2010, 19(3): 481-482 |
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| 作者姓名： | 王洪鹏 叶琳 王驰 陈鸿雁 |
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| 作者单位： | 1. 重庆医科大学附属第一医院,重庆,400016
2. 重庆医科大学,重庆,400016 |
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| 摘 要： | 目的 观察天然有效成分粉防己碱(Tetrandfine,TET)与常用抗肿瘤药物长春新碱(Vincristine,VCR)、平阳霉素(Bleomycin,BLM)、顺铂(Cisplatin,DDP)、5-Fu相互作用后,对鼻咽癌HNE-1细胞周期的影响.方法 以鼻咽癌HNE-1细胞株为研究对象,分为不加任何药物的对照组、抗肿瘤药物与TET合用组以及维拉帕米(Verapamil,VRP)与抗肿瘤药物合用组,采用流式细胞仪检测各组细胞周期的变化.结果 TET与抗肿瘤药物相互作用使实验细胞株发生明显的Go/G1期阻滞.TET与药物相互作用使实验细胞株也发生G0/C1期阻滞.TET与VRP与药物相互作用结果相似.结论 TET联合抗肿瘤药物后,可使鼻咽癌细胞株产生G1期阻滞,抑制细胞增殖,其作用与经典化疗增敏剂VRP相似,此结果为TET作为化疗增敏剂提供了依据.
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| 关 键 词： | 粉防己碱 细胞周期 抗肿瘤药 |
The Effect of Tetrandrine and Common Anti-cancer Drugs after Joint Action on Cell Cycle of the HNE-1 Cell Line |
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| WANG Hong-peng,YE Lin,WANG Chi,et al The First Affiliated Hospital,Chongqing Medical University Chongqing Medical University. The Effect of Tetrandrine and Common Anti-cancer Drugs after Joint Action on Cell Cycle of the HNE-1 Cell Line[J]. Journal of Emergency in Traditional Chinese Medicine, 2010, 19(3): 481-482 |
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| Authors: | WANG Hong-peng YE Lin WANG Chi et al The First Affiliated Hospital Chongqing Medical University Chongqing Medical University |
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| Affiliation: | WANG Hong-peng1,YE Lin1,WANG Chi2,et al1 The First Affiliated Hospital,Chongqing Medical University(Chongqing 400016) 2Chongqing Medical University(Chongqing 400016) |
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| Abstract: | Objective:To study the effect of tetrandrine(TET) and common anti-cancer drugs(vincristine,bleomycin,cisplatin,5-Fu) after joint action on cell cycle of the HNE-1.Methods:HNE-1 cell line was selected to carry out the experiment,the cells were divided into control group(without any drug) ,TET group(TET combined with anti-cancer drugs) and verapamil(VRP) group(VRP combined with anti-cancer drugs) .The cell cycle was detected by flow cytometry.Results:The cells of TET and VRP group reduced in the G0/G1 stage c... |
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| Keywords: | FCM |
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