血清铁蛋白在急性冠状动脉综合征临床应用研究中的作用

目的：探讨在急性冠状动脉综合征（ACS）患者中，血清铁蛋白（SF）与ACS及其他心血管疾病危险因素之间的相关性。方法选取ACS患者110例，其中不稳定性心绞痛（UA）组46例、非ST段抬高型心肌梗死（NSTEMI）组30例和ST段抬高型心肌梗死（STEMI）组34例；同期冠状动脉造影显示冠状动脉正常的患者为对照组42例，检测SF、超敏C反应蛋白（hs-CRP）和血脂水平，比较组间SF的差异并分析SF与hs-CRP及各血脂参数之间的相关性。结果 UA组、NSTEMI组、STEMI组与对照组比较SF水平显著升高（P＜0．05），且NSTEMI组、STEMI组明显高于 UA组。相关性分析显示，SF与hs-CRP、三酰甘油（TG）呈正相关，与高密度脂蛋白胆固醇（HDL-C）呈负相关。结论 SF在ACS患者中明显升高，且与hs-CRP、脂质代谢紊乱密切相关，SF检测有助于ACS患者临床分型和危险度分层。

The clinical application value of serum ferritin in acute coronary syndromes

Objective To investigate the relationship of serum ferritin(SF) and acute coronary syndrome(ACS) .Methods ACS group(n= 110) was divided into unstable angina(UA) subgroup(n= 46) ,non-ST-segment elevation myocardial infarction (NSTEMI) subgroup(n=30) and ST-segment elevation myocardial infarction(STEMI) subgroup(n=34) according to clinical da-ta ,coronary angiography and electrocardiogram examination .The normal coronary patients provided as control group(n=42) .The levels of serum ferritin ,hs-CRP and serum lipids were determined and the differences of SF among the groups were analyzed .The correlation of hs-CRP ,TG ,LDL-C ,HDL-C ,TC and SF were also analyzed .Results Compared with control group ,the level of SF in UA ,NSTEMI ,STEMI were significantly increased(P<0 .05) .Comparison in the levels of SF in NSTEMI ,STEMI group and UA group had significant difference(P<0 .05) .Correlation analysis indicated that the level of SF were positively correlated with hs-CRP ,TG and negatively associated with HDL-C .Conclusion The level of SF significantly increased in patients with ACS and has a positive relationship with hs-CRP and the disorder of lipid metablism .SF helps in assessing the clinical classification and risk strati-fication in patients with ACS .