CD24在子宫内膜异位症中的表达及其意义

目的观察CD24在子宫内膜异位症（内异症）中的表达，并探讨其在内异症发生、发展中的作用。方法采用免疫组化SP法检测48例内异症异位内膜组、48例内异症在位内膜组和30例正常内膜（对照组）标本及子宫内膜腺上皮细胞、间质细胞、不同月经周期中CD24的表达情况。结果内异症异位内膜组、内异症在位内膜组CD24阳性表达率均显著高于对照组（P均〈0．05）。内异症异位内膜组、内异症在位内膜组子宫内膜腺上皮细胞中CD24阳性表达率均显著高于对照组（P均〈0．01）。内异症在位内膜组子宫内膜间质细胞中CD24阳性表达率显著高于对照组（P〈0．05）。内异症在位内膜组增生期、内异症异位内膜组增生期、对照组增生期、分泌期CD24阳性表达率均显著低于内异症在位内膜组分泌期（P均〈0．05）。结论CD24在内异症的发病中有一定的作用。

The Expression and Significance of CD24 in Endometriosis

Objective To observe the expression of CD24 in women with endometriosis and to elucidate the role of CD24 in the pathogenesis of endometriosis. Methods Imunohistochemical SP method was used to measure the expression of the CD24 in ectopic endometrium group （n= 48） with endometriosis, eutopic endometrium group （n=48） with endometriosis and endometrium from women with benign diseases （n = 30, control group）specimens and the expression of the CD24 in glandular epithelial cells of endometrium, stromal cells of endometrium and different menstruation circles. Results The positive rate of CD24 was significantly higher in ectopic and eutopic endometrium groups with endometriosis than those in control group（all P〈0.05）. The positive rate of CD24 was significantly higher in glandular epithelial cells than in stromal cells in ectopic and eutopic endometrium group with endometriosis and control group（all P〈0.01）. The positive rate of CD24 was significantly higher in stromal cells in eutopic endometrium than those in control group（P〈0.05）. The positive rate of CD24 was significantly lower in ectopic and eutopic endometrium group in proliferative phase, control group in proliferative phase, secretory phase than in eutopic endometrium in secretory phase （all P〈0.05）. Conclusion CD24 may play an important role in the pathogenesis of endometriosis.