| 酮洛芬的相转移催化氧化合成 |
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| 引用本文： | 范琦,程秀华,张琴,蒋心惠,朱凯. 酮洛芬的相转移催化氧化合成[J]. 中国医药工业杂志, 2005, 36(11): 664-665 |
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| 作者姓名： | 范琦 程秀华 张琴 蒋心惠 朱凯 |
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| 作者单位： | 1. 重庆医科大学药学系,重庆,400016
2. 西南合成制药股份有限公司药物研究所,重庆,400025 |
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| 摘 要： | 2-(3-苄基苯基)丙醛和高锰酸钾在相转移催化剂度米芬作用下,以苯为有机相、氢氧化钠水溶液为水相氧化制得酮洛芬,收率69%,纯度99.5%.
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| 关 键 词： | 酮洛芬 非甾体抗炎药 相转移催化氧化 合成 |
| 文章编号： | 1001-8255（2005）11-0654-02 |
| 收稿时间： | 2004-10-08 |
| 修稿时间： | 2004-10-08 |
Synthesis of Ketoprofen by Phase Transfer Catalytic Oxidation |
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| FAN Qi,CHENG Xiu-Hua,ZHANG Qin,JIANG Xin-Hui,ZHU Kai. Synthesis of Ketoprofen by Phase Transfer Catalytic Oxidation[J]. , 2005, 36(11): 664-665 |
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| Authors: | FAN Qi CHENG Xiu-Hua ZHANG Qin JIANG Xin-Hui ZHU Kai |
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| Affiliation: | 1. Dept. of Pharmacy, Chongqing University of Medical Sciences, Chongqing 400016; 2. Production Dept., Southwest Synthetic Pharmaceutical Co. Ltd., Chongqing 400025 |
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| Abstract: | Ketoprofen was synthesized from 2-(3-benzylphenyl)propionaldehyde by phase transfer catalytic oxida-tion with KMnO4 in presence of domiphen bromide using benzene as organic phase and NaOH solution as aqueous phasein 69% yield and purity of 99.5%. |
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| Keywords: | ketoprofen NSAIDs phase transfer catalytic oxidation synthesis |
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