| 乳化剂对阿司匹林微球制备的影响 |
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| 引用本文： | 冼远芳,侯瑞珍.乳化剂对阿司匹林微球制备的影响[J].中国医院药学杂志,2007,27(3):324-327. |
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| 作者姓名： | 冼远芳 侯瑞珍 |
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| 作者单位： | 长春工业大学化工学院,吉林,长春,130012 |
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| 摘 要： | 目的:用溶剂挥发法以聚乳酸为载体制得阿司匹林聚乳酸微球。方法:选择不同的乳化剂,用正交设计安排实验。并以微球包埋率、载药量、表面形态、体外释放为指标优化微球的制备工艺。结果:按优化条件制得的微球包埋率39.5%,载药量7.25%,体外释药t1/2为3d。结论:制备微球缓释效果明显。
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| 关 键 词： | 阿司匹林 聚乳酸 乳化挥发法 正交实验 缓释微球 |
| 文章编号： | 1001-5213(2007)03-0324-04 |
| 修稿时间： | 2006-07-26 |
Preparation of polylactic acid enveloped aspirin microspheres and its release in vitro |
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| XIAN Yuan-fang,HOU Ruai-zhen.Preparation of polylactic acid enveloped aspirin microspheres and its release in vitro[J].Chinese Journal of Hospital Pharmacy,2007,27(3):324-327. |
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| Authors: | XIAN Yuan-fang HOU Ruai-zhen |
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| Institution: | school of chemical Engineering, Changchun University of Technology, Jilin Changchun 130012,China |
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| Abstract: | OBJECTIVE Polyactic acid enveloped aspirin microspheres were prepared by the solvent evaportion method.METHODS The orthogonal tast of 3 factors and 3 levels was applied to optinize the preparation procedure of with indexes of particle appearance,drug content,rate of encapsulation.RESULTS Micropheres were obtained drug content of 7.25% and encap sulated rate of 39.5%.t1/2(in vitro)were 70 h.CONCLUSION The results showed the microspheres prepared by the method had obviously release effect. |
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| Keywords: | aspirin polylactic acid emulsion-solvent evaporation method orthogonal tast release microspheres |
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