| 乳腺癌耐药蛋白的研究进展 |
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| 引用本文： | 刘晓健,孙孟红,施达仁. 乳腺癌耐药蛋白的研究进展[J]. 中国癌症杂志, 2004, 14(3): 286-288 |
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| 作者姓名： | 刘晓健 孙孟红 施达仁 |
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| 作者单位： | 复旦大学附属肿瘤医院病理科,上海,200032 |
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| 摘 要： | 乳腺癌耐药蛋白(BVRP)是新近发现的一种肿瘤耐药相关蛋白．与P-gp和多药耐药相关蛋白(MRP)同属ABC转运蛋白超家族。本文对BCRP的发现、基因表达特征、与造血干细胞分化的关系、转运底物及其耐药逆转和临床意义等方面的研究进展进行综述。
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| 关 键 词： | 多药耐药 乳腺癌 基因表达 |
| 文章编号： | 1007-3639(2004)03-0286-03 |
| 修稿时间： | 2003-11-08 |
Research advances in breast cancer resistance protein (BCRP) |
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| LIU Xiao-jian,SUN Meng-hong,SHI Da-ren. Research advances in breast cancer resistance protein (BCRP)[J]. China Oncology, 2004, 14(3): 286-288 |
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| Authors: | LIU Xiao-jian SUN Meng-hong SHI Da-ren |
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| Abstract: | WTBZ]Breast cancer resistance protein (BCRP) is a recently discovered half-transporter belonging to the ABC transporter superfamily as P-glycoprotein(P-gp) and multiple resistance protein (MRP). The latest research results concerned BCRP on construction features of gene, relationship to differentiation of hemopoietic stem cell and correlated transport substrates were reviewed in the article and it's clinical significance was mentioned at the same time. |
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| Keywords: | multidrug resistance breast cancer gene expression |
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