cAMP and cGMP in the cerebrospinal fluid of patients with multiple sclerosis

The authors studied the changes in cAMP and cGMP concentrations in the cerebrospinal fluid in 38 patients with multiple sclerosis. A statistically significant fall of cAMP was observed with a simultaneous rise of cGMP in the initial stage of the disease as compared with the control group. In the later course of the disease and development of various clinical forms of multiple sclerosis the pattern of these changes was not characteristic.