偏头痛患者血浆一氧化氮、内皮素、5-羟色胺含量检测及其意义

为探讨一氧化氮、内皮素及５－羟色胺引发偏头痛的机制及其临床意义，对６８例偏头痛患者用分光光度法测定血浆ＮＯ、放射免疫法测定ＥＴ、Ａ荧光分光法测定５－ＨＴ含量。结果发现偏头痛发作期血浆ＮＯ、ＥＴ含量明显高于对照组，而５－ＨＴ含量明显低于对照组；

DETERMINATIONS OF PLASMA NITRIC OXIDE, ENDOTHELIN AND 5 HT IN PATIENTS WITH MIGRAINE AND THEIR SIGNIFICANCE

To explore the machanism of migraine induced by nitric oxide (NO), endothelin (ET) and 5 hydroxytryptamine (5 HT), and their clinical significance, assays for plasma concentrations of NO with spectrotometry, ET with radioimmunoassay, 5 HT with fluorescence spectrotometry were performed in 68 cases of migraine. The results showed that in the attack stage of migraine, the concentrations of plasma NO and ET were remarkably higher than the control group ( P <0.01), while the concentration of 5 HT was markedly lower than the control group ( P <0.01). The concentrations of plasma NO in the aura stage and the interim stage had no difference from that in the control group; the concentration of plasma ET in aura stage had great difference from the control group ( P <0.05). ET in the interim stage had no difference from the control group. The concentration of plasma 5 HT in the aura and interim stages was remarkably higher than the attack stage ( P < 0.01). It was concluded that 5 HT was the basis of migraine attack and the inducer and activator of NO and ET. NO was the main factor to cause the vasodilation, resulting in migraine attack; ET might be the important factor to cause vasoconstriction, resulting in the portent symptoms.