| HPLC法测定康艾注射液中氧化苦参碱的含量 |
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| 引用本文： | 王亮,杨晓云.HPLC法测定康艾注射液中氧化苦参碱的含量[J].中国药师,2011,14(11):1632-1633. |
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| 作者姓名： | 王亮 杨晓云 |
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| 作者单位： | 青岛市药品检验所,山东青岛,266071 |
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| 摘 要： | 目的:建立康艾注射液中氧化苦参碱含量的高效液相测定方法。方法:色谱柱:Agilent氨基柱（250mm×4.6mm,5μm）,流动相:乙腈-无水乙醇-3%磷酸溶液（80:10:10）,检测波长:220nm,柱温:30℃,流速:1.0ml·min-1。结果:氧化苦参碱线性范围为5.63～28.15μg（r=0.999 8）,平均回收率为100.6%,RSD=0.29%（n=7）。结论:本法简便,准确,重复性好,可用于康艾注射液的质量控制。
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| 关 键 词： | 康艾注射液 氧化苦参碱 高效液相色谱法 |
Determination of Oxymatrine in Kangai Injection by HPLC |
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| Wang Liang,Yang Xiaoyun.Determination of Oxymatrine in Kangai Injection by HPLC[J].China Pharmacist,2011,14(11):1632-1633. |
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| Authors: | Wang Liang Yang Xiaoyun |
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| Institution: | (Qingdao Institute for Drug Control, Shandong Qingdao 266071, China) |
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| Abstract: | Objective： To establish a method for the determination of oxymatrine in Kangai injection by HPLC. Method： The HPLC analysis was performed on an Agilent amino column （250 mm × 4. 6 mm,5 μm）, the mobile phase was acetonitrile - ethanol- 3% H3PO4 （80： 10： 10） with a flow rate of 1.0 ml. min^-1, the detection wavelength was 220 nm and the column temperature was 30℃. Result： The linear range of oxymatrine was 5.63-28. 15 μg （r = 0. 999 8）, and the average recovery was 100. 6% with RSD of 0. 29% （n = 7）. Conclusion： The method is convenient, accurate and suitable for the quality control of Kangai injection. |
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| Keywords: | Kangai injection Oxymatrine HPLC |
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