| 73例抗肿瘤药物致肝损害不良反应/事件分析 |
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| 引用本文： | 甘戈,顾成杰.73例抗肿瘤药物致肝损害不良反应/事件分析[J].中国药物警戒,2011,8(11):690-693. |
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| 作者姓名： | 甘戈 顾成杰 |
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| 作者单位： | 1. 江苏省药品不良反应监测中心,江苏南京,210002
2. 南京医科大学,江苏南京,210029 |
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| 摘 要： | 目的 探讨抗肿瘤药物致肝损害的特点和规律.方法 采用回顾性研究方法,对2004年至2010年6月江苏省药品不良反应监测中心收集的73例抗肿瘤药物致肝损害不良反应/事件报告进行综合分析.结果73例药品不良反应报告表中涉及44种抗肿瘤药物,其中顺铂、吉西他滨、阿糖胞苷位居前三位；静脉用药不良反应发生比例最高,占86.3％；...
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| 关 键 词： | 抗肿瘤药物 肝损害 药品不良反应/事件 吉西他滨 |
Analysis of 73 Adverse Drug Reaction/Event Reports on Liver Damage Induced by Anticancer Drugs |
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| GAN Ge,GU Cheng-jie.Analysis of 73 Adverse Drug Reaction/Event Reports on Liver Damage Induced by Anticancer Drugs[J].Chinese JOurnal of Pharmacovigilance,2011,8(11):690-693. |
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| Authors: | GAN Ge GU Cheng-jie |
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| Institution: | GAN Ge1 GU Cheng-jie2(1Jiangsu Center for ADR Monitoring,Jiangsu Nanjing 210002,China,2Nanjing Medical University,Jiangsu Nanjing 210029,China) |
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| Abstract: | Objective To investigate the epidemiological characteristics of liver damage induced by anticancer drugs. Methods With retrospective case study, analyzed 73 liver damage ADR/ADE reports induced by anticancer drugs in Jiangsu province from 2004 to June 2010. Results 73 ADR/ADE reports included 44 anticancer drugs, and the incidences of liver damage by Cisplatin,Gemcitabine and Vidarabine occupied the front 3 places in sequence. The drugs for intravenous administration resuked in the highest rate（86.3%）, and most of the patients have ADR/ADE in 1-2 weeks. The clinical manifestations were jaundice, fatigue, fever, abdominal distension, abdominal pain, dark urine, nausea, edema, chest tightness, rash, itching, anorexia. Liver function examination showed that alanine amino transferase was in 48-2 610 U/L, and total bilirubin was in 6.7-260.1μmol/L in average. Conclusion It should be strengthening the observation and evaluation of liver damage induced by anticancer drugs. |
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| Keywords: | anticancer drugs liver damage adverse drug reaction/event(ADR/ADE) gemcitabine |
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