地高辛对小鼠吗啡行为敏化的影响

目的:探讨地高辛对小鼠吗啡行为敏化的影响.方法:测定小鼠的自主活动,观察地高辛对小鼠自主活动的影响.急性吗啡(10 mg·kg-1,ip)处理小鼠前给予地高辛,观察地高辛对急性吗啡引起小鼠高活动性的影响.慢性吗啡处理小鼠,建立吗啡行为敏化模型,观察地高辛对吗啡行为敏化的影响.结果:(1)地高辛(0.5 mg·kg-1-...

DIGOXIN INHIBITED THE DEVELOPMENT AND THE EXPRESSION OF MORPHINE-INDUCED SENSITIZATION IN MICE

Objective:To investigate the effects of digoxin on morphine induced behavioral sensitization.Methods:Locomotor activity was measured every 15 min for 2 hours after administration with digoxin in mice.The animals were rendered sensitization to morphine via treatment with morphine(10 mg ·kg-1,ip) for 5 days.After cessation of drugs for 7 days,all animals were challenged with morphine(10 mg ·kg-1,ip) on 12th day.Results:Digoxin dose-dependently inhibited both locomotor activity in mice and hyperlocomotion induced by acute morphine.Similar inhibition was also seen both in the development and the expression of morphine-induced behavioral sensitization.Conclusion:Digoxin inhibits both in the development and the expression of morphine-induced behavioral sensitization in mice.And the inhibitory effects of digoxin on dopamine release in brain may account for this.These findings indicate that digoxin may have the interferential potential to psychological dependence on morphine,and Na+,K+/ATPase might serve as a drug target in morphine addiction.