| 利奈唑胺群体药代/药效动力学研究进展 |
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| 引用本文： | 张雷,刘又宁. 利奈唑胺群体药代/药效动力学研究进展[J]. 中国药物应用与监测, 2011, 8(5): 315-318 |
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| 作者姓名： | 张雷 刘又宁 |
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| 作者单位： | 解放军总医院呼吸内科,北京,100853 |
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| 摘 要： | 利奈唑胺属于新型口恶唑烷酮类药物,对于耐药革兰阳性球菌引起的社区、院内感染均有良好的临床疗效和安全性。本文综述了非线性混合效应模型法在群体药代/药效动力学研究中的作用及其在利奈唑胺研究的应用进展。
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| 关 键 词： | 利奈唑胺 革兰阳性球菌 群体药代动力学 |
Advance of population pharmacokinetics/pharmacodynamics on linezolid research |
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| ZHANG Lei,LIU You-ning. Advance of population pharmacokinetics/pharmacodynamics on linezolid research[J]. , 2011, 8(5): 315-318 |
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| Authors: | ZHANG Lei LIU You-ning |
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| Affiliation: | ZHANG Lei,LIU You-ning(Department of Respiratory Diseases,PLA General Hospital,Beijing 100853,China) |
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| Abstract: | Linezolid,a new drug of oxazolidinone,has satisfying clinical efficacy and safety on community-acquired or hospital-acquired infection resulting from gram-positive cocci.We reviewed the priority of nonlinear mixed-effects modeling for analysis of population pharmacokinetics/ pharmacodynamics,and the present advances of population pharmacokinetics/ pharmacodynamics on linezolid research. |
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| Keywords: | Linezolid Gram-positive cocci Population pharmacokinetics |
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