| 气相色谱法测定消肿止痛酊中樟脑、薄荷脑的含量 |
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| 引用本文： | 钟妍.气相色谱法测定消肿止痛酊中樟脑、薄荷脑的含量[J].中国药师,2011,14(11):1616-1618. |
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| 作者姓名： | 钟妍 |
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| 作者单位： | 广西壮族自治区食品药品检验所,南宁,530021 |
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| 摘 要： | 目的:建立气相色谱法测定消肿止痛酊中的樟脑、薄荷脑的含量。方法:色谱柱:DB-WAX石英毛细管柱（30m×0.53mm,1μm）,柱温为120～180℃程序升温,升温速率为3℃·min-1;FID检测器,检测器温度为230℃;内标为萘。结果:樟脑进样量在0.200～2.002μg范围内线性良好（r=0.9993,n=5）;平均回收率为97.74%,RSD=1.24%。薄荷脑进样量在0.202～2.017μg范围内线性良好（r=0.9991,n=5）;回收率为99.00%,RSD=1.43%。结论:本方法简便、准确,可用作消肿止痛酊的质量控制。
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| 关 键 词： | 气相色谱法 消肿止痛酊 樟脑 薄荷脑 |
Determination of Camphor and Menthol in Xiaozhong Zhitong Tincture by GC |
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| Zhong Yan.Determination of Camphor and Menthol in Xiaozhong Zhitong Tincture by GC[J].China Pharmacist,2011,14(11):1616-1618. |
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| Authors: | Zhong Yan |
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| Institution: | Zhong Yan( Guangxi Zhuang Autonomous Region Institute for Food and Drug Control, Nanning 530021, China) |
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| Abstract: | Objective： To establish a GC method for the determination of camphor and menthol in Xiaozhong Zhitong tincture. Method： Chromatographic column was a DB-WAX capillary column （30 m ×0. 53 mm,1 μm）. The column temperature programming was from 120 ℃ to 180℃ at a rate of 3℃ .min-1. FID was applied with temperature of 230 ℃. The quantitative determination was performed with uaphthalin as the internal standard. Result： The linear range of camphor was within 0. 200-2. 002 tLg （ r = 0. 999 3, n = 5）, and the average recovery was 97.74% （ RSD = 1.24% ）. The linear range of menthol was within 0. 202-2. 017 μg （ r = 0. 999 1, n =5） ,and the average recovery was 99.00% （RSD = 1.43% ）. Conclusion： This method can be used in the quality control of Xi- aozhonz Zhitonz tincture. |
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| Keywords: | Xiaozhong Zhitong tincture Camphor Menthol GC |
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