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气相色谱法测定消肿止痛酊中樟脑、薄荷脑的含量
引用本文:钟妍.气相色谱法测定消肿止痛酊中樟脑、薄荷脑的含量[J].中国药师,2011,14(11):1616-1618.
作者姓名:钟妍
作者单位:广西壮族自治区食品药品检验所,南宁,530021
摘    要:目的:建立气相色谱法测定消肿止痛酊中的樟脑、薄荷脑的含量。方法:色谱柱:DB-WAX石英毛细管柱(30m×0.53mm,1μm),柱温为120~180℃程序升温,升温速率为3℃·min-1;FID检测器,检测器温度为230℃;内标为萘。结果:樟脑进样量在0.200~2.002μg范围内线性良好(r=0.9993,n=5);平均回收率为97.74%,RSD=1.24%。薄荷脑进样量在0.202~2.017μg范围内线性良好(r=0.9991,n=5);回收率为99.00%,RSD=1.43%。结论:本方法简便、准确,可用作消肿止痛酊的质量控制。

关 键 词:气相色谱法  消肿止痛酊  樟脑  薄荷脑

Determination of Camphor and Menthol in Xiaozhong Zhitong Tincture by GC
Zhong Yan.Determination of Camphor and Menthol in Xiaozhong Zhitong Tincture by GC[J].China Pharmacist,2011,14(11):1616-1618.
Authors:Zhong Yan
Institution:Zhong Yan( Guangxi Zhuang Autonomous Region Institute for Food and Drug Control, Nanning 530021, China)
Abstract:Objective: To establish a GC method for the determination of camphor and menthol in Xiaozhong Zhitong tincture. Method: Chromatographic column was a DB-WAX capillary column (30 m ×0. 53 mm,1 μm). The column temperature programming was from 120 ℃ to 180℃ at a rate of 3℃ .min-1. FID was applied with temperature of 230 ℃. The quantitative determination was performed with uaphthalin as the internal standard. Result: The linear range of camphor was within 0. 200-2. 002 tLg ( r = 0. 999 3, n = 5), and the average recovery was 97.74% ( RSD = 1.24% ). The linear range of menthol was within 0. 202-2. 017 μg ( r = 0. 999 1, n =5) ,and the average recovery was 99.00% (RSD = 1.43% ). Conclusion: This method can be used in the quality control of Xi- aozhonz Zhitonz tincture.
Keywords:Xiaozhong Zhitong tincture  Camphor  Menthol  GC
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