冠状动脉局部血流动力学参数分析及斑块预警研究

目的探讨应用计算流体动力学（computational fluid dynamics，CFD）技术构建个体化正常人冠状动脉血流动力学模型的方法，探索冠脉局部血流动力学参数分布情况及各参数与冠状动脉粥样硬化病变的关系。方法以CT图像为基础进行冠状动脉三维几何建模，构建个体化冠状动脉血流动力学模型，对正常人体左冠状动脉前降支局部进行数值模拟，应用有限体积法进行血流数值模拟。结果获得个体化正常左冠状动脉前降支血管树模型及血流动力学参数，数值模拟结果包括冠状动脉的血液流场、壁面压力（wall pressure，WP）、壁面切应力（wall shear stress，WSS）分布，可见各参数呈不规则分布，在血管弯曲分叉部位靠近管壁处血流明显减速、血管发出分支区域出现高WP、WSS分布，而这些区域的对侧血管壁对应不均匀的低WP、WSS分布。结论以CT图像为基础的数值模拟技术可以重建个体化冠状动脉血流动力学模型，为分析血流动力学参数与冠状动脉粥样硬化形成的关系提供研究手段。

Local coronary artery hemodynamics and plaques

Objective To study the local coronary artery parameters and their relation with coronary atherosclerosis by establishing the normal coronary artery hemodynamics model using computational fluid dynamics （CFD） techniques. Methods A 3D geometric model of coronary artery hemodynamics was established according to the CT images. Numerical value was simulated for the anterior descending branch of normal left coronary artery and blood flow value was simulated with the finite volume. Results The anterior descending branch model of normal left coronary artery tree was established and its hemodynamic parameters were displayed, including streamlines of blood velocity, wall pressure （WP）, and wall shear stress （WSS）. The parameters were irregularly distributed. The blood flow velocity was significantly lower at the outer walls of bifurcations with high WP and WSS, and low WP and WSS at the opposite side of vascular walls. Conclusion CT image-based numerical value simulation technique can be used in establishing coronary artery hemodynamics model, and in analyzing the relation between hemodynamics parameters and coronary atherosclerosis.