INVOLVEMENT OF SYMPATHETIC NERVOUS SYSTEM INHIBITION IN THE HYPOTENSIVE EFFECT OF BROMOCRIPTINE IN SPONTANEOUSLY HYPERTENSIVE RATS |
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| Authors: | Y Kanayama M Kohno K Takaori S Itoh K Yasunari T Takeda |
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| Institution: | The First Department of Internal Medicine, Osaka City University Medical School, 1–5–7, Asahimachi, Abeno-ku, Osaka 545, Japan |
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| Abstract: | The hypotensive effect of bromocriptine in young (6 week old) spontaneously hypertensive rats (SHR) was studied. Blood pressure and plasma norepinephrine level in bromocriptine-treated SHR were significantly lower than those in vehicle-treated SHR after 3 weeks of treatment (5 mg/kg per day, i.p.), while no significant decrease of blood pressure or plasma norepinephrine level was observed after 2 weeks of treatment. These results suggest the involvement of sympathetic nervous system inhibition in the hypotensive effect of bromocriptine in SHR. |
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| Keywords: | bromocriptine epinephrine hypotensive effect norepinephrine spontaneously hypertensive rats |
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