A型肉毒毒素治疗难治性三叉神经痛临床观察

目的：评价A型肉毒毒素（BTX-A）治疗难治性三叉神经痛的疗效。方法：选取难治性三叉神经痛患者6例,其中原发性5例,继发性1例。采用视觉模拟评分（VAS）于局部多点注射BTX-A,予治疗前及治疗后2周、2个月和6个月时进行疼痛测评。结果：VAS评分：BTX-A治疗前为（8.86±0.75）分;BTX-A注射后2周和2个月分别降至（1.00±1.26）分和（2.00±2.45）分,与治疗前比,差异均有统计学意义（P〈0.05）;6个月时为（5.33±2.16）分,与治疗前比,差异仍有统计学意义（P〈0.05）。6例患者均无明显并发症出现。结论：BTX-A注射治疗难治性三叉神经痛是一种安全有效的新疗法。

A Study of Botulinum A Toxin Treatment of Intractable Trigeminal Neuralgia

Aim：To investigate the effects of local injections of botulinum toxin type A （BTX-A） on patients with intractable trigeminal neuralgia. Methods：Six patients were treated with BTX-A. Five patients diagnosis were idiopathic trigeminal neuralgia,and only one was secondary. Visual analog scores（VAS） was utilized to measure the degree of the pain. VAS were measured at 2 weeks,2 months and 6 months after the treatment. Results：The VAS were 8.86±0.75 before the BTX-A treatment. The scores were 1.00±1.26（P0.05） and 2.00±2.45（P0.05） at 2 weeks and 2 months after the treatment,respectively. After 6 months VAS was 5.33±2.16（P0.05）,there was significant statistical difference compared with the VAS before the treatment. No severe side effects were observed in the six patients. Conclusion：The study suggested that BTX-A may be an effective and novel means in the management of patients with trigeminal neuralgia.