Atorvastatin prevents age-related and amyloid-β-induced microglial activation by blocking interferon-γ release from natural killer cells in the brain |
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Authors: | Anthony Lyons Kevin J Murphy Rachael Clarke Marina A Lynch |
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Institution: | (1) Trinity College Institute for Neuroscience, Physiology Department, Trinity College, Dublin 2, Ireland |
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Abstract: | Background Microglial function is modulated by several factors reflecting the numerous receptors expressed on the cell surface, however
endogenous factors which contribute to the age-related increase in microglial activation remain largely unknown. One possible
factor which may contribute is interferon-γ (IFNγ). IFNγ has been shown to increase in the aged brain and potently activates
microglia, although its endogenous cell source in the brain remains unidentified. |
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