| 前列地尔乳剂的特殊安全性实验研究 |
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| 引用本文： | 李萍,刘宏大,王宏英,薛雁,薛百忠,潘月军.前列地尔乳剂的特殊安全性实验研究[J].中国医药导报,2011,8(1):53-54. |
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| 作者姓名： | 李萍 刘宏大 王宏英 薛雁 薛百忠 潘月军 |
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| 作者单位： | 1. 辽宁诺康生物制药有限责任公司,辽宁沈阳,110171
2. 吉林省育华药业有限责任公司,吉林长春,130122 |
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| 摘 要： | 目的：评价前列地尔乳剂的安全性。方法：采兔血配制成2％的红细胞混悬液，进行溶血试验；兔耳缘静脉分别注射前列地尔乳剂和生理盐水，观察药物对血管的刺激性；豚鼠腹腔注射前列地尔乳剂，观察过敏反应。结果：前列地尔乳剂对兔红细胞未出现溶血和凝聚作用；家兔耳缘静脉未见明显刺激作用；豚鼠仅出现轻微搔鼻或颤抖反应，未引起死亡。结论：前列地尔乳剂无溶血作用，无血管刺激性，无过敏反应，安全性符合要求。
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| 关 键 词： | 乳剂 前列地尔 特殊安全性 |
Special safety study on Alprostadil Emulsion |
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| LI Ping,LIU Hongda,WANG Hongying,XUE Yan,XUE Baizhong,PAN Yuejun.Special safety study on Alprostadil Emulsion[J].China Medical Herald,2011,8(1):53-54. |
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| Authors: | LI Ping LIU Hongda WANG Hongying XUE Yan XUE Baizhong PAN Yuejun |
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| Institution: | LI Ping1,LIU Hongda1,WANG Hongying1,XUE Yan1,XUE Baizhong1,PAN Yuejun2(1.Liaoning Nuokang Bio-pharmaceutical Co.Ltd.,Shenyang 110171,China,2.Jilin Yuhua Pharmaceutical Co.Ltd.,Changchun 130122,China) |
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| Abstract: | Objective: To evaluate the safty of Alprostadil Emulsion.Methods: Preparated rabbit blood into 2% erythrocyte suspension for hemolytic test.In order to observe the stimulation vessel,Alprostadil Emulsion and 0.9% Sodium chloride injection were injected into ear vein of rabbit respectively.The allergic response on guinea pig in vitro were performed.Results: It was showed that the Alprostadil Emulsion had no hemolysis and agglomeration effects on the red blood cell of rabbit while no significant stimulation o... |
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| Keywords: | Emulsion Alprostadil Special safety |
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