| 慢性束缚心理应激对大鼠血管内皮结构和功能的影响 |
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| 引用本文： | 吴相锋,来静,吴相春,贾振华,王宏涛,赵韶华. 慢性束缚心理应激对大鼠血管内皮结构和功能的影响[J]. 疑难病杂志, 2011, 10(2): 123-125,165. DOI: 10.3969/j.issn.1671-6450.2011.02.021 |
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| 作者姓名： | 吴相锋 来静 吴相春 贾振华 王宏涛 赵韶华 |
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| 作者单位： | 1. 河北以岭医药研究院络病室,石家庄,050035
2. 石家庄市第三医院急诊科,050017 |
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| 基金项目： | ,国家重点基础研究发展计划(国家973计划)资助项目,国家十一五重大新药创制项目 |
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| 摘 要： | 目的探讨慢性束缚心理应激对大鼠血管内皮结构和功能的影响及其机制。方法 20只清洁级Wistar大鼠随机分为对照组与模型组,采用重复束缚法6周建立心理应激反应模型,放免法检测血浆内皮素(ET),硝酸还原酶法检测血清NO;循环酶法测定血清同型半胱氨酸(Hcy)水平;光镜观察胸主动脉形态学变化,透射电镜观察主动脉组织内皮细胞超微结构变化;免疫组化法检测主动脉组织中内皮素-1(ET-1)的表达。结果模型组大鼠血浆ET含量及血清Hcy含量较对照组明显升高,血清NO明显下降(P<0.05或P<0.01);主动脉组织中ET-1高度表达;内皮细胞超微结构明显改变。结论慢性束缚心理应激可引起大鼠明显的血管内皮结构和功能的损伤,其机制可能与血清Hcy水平升高有关。
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| 关 键 词： | 束缚应激,慢性 血管内皮 结构 功能 大鼠 |
Influence of chronic constraint psychological stress on the construction and function in vascular endothelial of rats |
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| WU Xiang-feng,LAI Jing,WU Xiang-chun,et al.. Influence of chronic constraint psychological stress on the construction and function in vascular endothelial of rats[J]. Journal of Difficult and Complicated Cases, 2011, 10(2): 123-125,165. DOI: 10.3969/j.issn.1671-6450.2011.02.021 |
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| Authors: | WU Xiang-feng LAI Jing WU Xiang-chun et al. |
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| Affiliation: | WU Xiang-feng,LAI Jing,WU Xiang-chun,et al.Research Department of Collateral Diseases,Hebei Yiling Pharmaceutical Research Institute,Shijiazhuang 050035,China |
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| Abstract: | Objective To investigate the influence on the construction and function in vascular endothelial of rats with chronic constraint psychological stress and explore mechanism.Methods Twenty healthy male Wistar rats of sanitary degree were randomly divided into the normal control group and the psychological stress model group.To establish the chronic psychological stress model by repeated restraint for 6 weeks.The content of plasma endothelin(ET) was detected with radioimmunoassay, serum nitro oxygen(NO) was det... |
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| Keywords: | Restraint stress chronic Vascular endothelium Structure Function Rats |
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