| 益肾蠲痹丸治疗强直性脊柱炎临床疗效观察 |
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| 引用本文： | 陈培荣,林进,丁振华,吴华香,陈士芳,王宏智,朱小春.益肾蠲痹丸治疗强直性脊柱炎临床疗效观察[J].中华中医药学刊,2012(11):2506-2508. |
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| 作者姓名： | 陈培荣 林进 丁振华 吴华香 陈士芳 王宏智 朱小春 |
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| 作者单位： | 温州医学院附属第一医院风湿免疫科;浙江大学医学院附属第一医院风湿免疫科;丽水市人民医院风湿免疫科;浙江大学医学院附属第二医院风湿免疫科;湖州市中心医院风湿免疫科;嘉兴市第一医院风湿科 |
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| 基金项目： | 浙江省医学会临床科研基金资助项目(200709) |
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| 摘 要： | 目的:探讨益肾蠲痹丸对强直性脊柱炎(Ankylosing Spondylitis,AS)的疗效及安全性。方法:入选67例早中期AS患者,随机分3组:治疗组(益肾蠲痹丸+双氯芬酸片)、阳性对照组(柳氮磺吡啶+双氯芬酸片)和联合治疗组(益肾蠲痹丸+柳氮磺吡啶+双氯芬酸片)。分别观察治疗前、实验中期(治疗3个月)及实验结束(治疗6个月)AS活动指数(BASDAI)、AS测量指数(BASMI)、AS功能指数(BASFI)、血沉(ESR)、C-反应蛋白(CRP)的变化及药物不良反应。结果:实验中期及结束时三组Bath指数和实验室指标比治疗前均有改善,临床症状有所缓解,实验中期3组间疗效无统计学差异(P=0.193),实验结束时联合治疗组效果优于治疗组或阳性对照组,有统计学差异(P=0.023、P=0.026)。各组不良反应以胃肠道反应为主,3组比较无统计学差异(P0.05)。结论:益肾蠲痹丸联合柳氮磺吡啶治疗早中期活动性AS患者6个月疗效显著,且不良反应轻微。
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| 关 键 词： | 强直性脊柱炎 益肾蠲痹丸 柳氮磺吡啶 |
Efficacy of Yishen Juanbi Oill on Ankylosing Spondylitis |
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| CHEN Pei-rong,LIN Jin,DING Zhen-hua,WU Hua-xiang,CHEN Shi-fang,WANG Hong-zhi,ZHU Xiao-chun.Efficacy of Yishen Juanbi Oill on Ankylosing Spondylitis[J].Chinese Archives of Traditional Chinese Medicine,2012(11):2506-2508. |
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| Authors: | CHEN Pei-rong LIN Jin DING Zhen-hua WU Hua-xiang CHEN Shi-fang WANG Hong-zhi ZHU Xiao-chun |
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| Institution: | 1(1.Department of Rheumatology,The First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000,Zhejiang,China; 2.Department of Rheumatology,The First Affiliated Hospital of Medical School of Zhejiang University,Hangzhou 310014,Zhejiang,China; 3.Department of Rheumatology,The People’s Hospital of Lishui City,Lishui 323000,Zhejiang,China; 4.Department of Rheumatology,The Second Affiliated Hospital of Medical School of Zhejiang University,Hangzhou 310014,Zhejiang,China; 5.Department of Rheumatology,The Center Hospital of Huzhou City,Huzhou 313000,Zhejiang,China; 6.Department of Rheumatology,The First Hospital of Jiaxing City,Jiaxing 314000,Zhejiang,China) |
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