| 骨碎补总黄酮对胶原诱导性关节炎大鼠关节骨破坏影响的实验研究 |
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| 引用本文： | 高华利,肖涟波,张子峰,欧阳桂林,黄新星,李宁丽,胡军林,黄志明,黄正,解骏.骨碎补总黄酮对胶原诱导性关节炎大鼠关节骨破坏影响的实验研究[J].中国骨伤,2013,26(9):764-767. |
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| 作者姓名： | 高华利 肖涟波 张子峰 欧阳桂林 黄新星 李宁丽 胡军林 黄志明 黄正 解骏 |
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| 作者单位： | 上海光华中西医结合医院脊柱外科, 上海 200052;上海光华中西医结合医院脊柱外科, 上海 200052;上海光华中西医结合医院脊柱外科, 上海 200052;上海光华中西医结合医院脊柱外科, 上海 200052;上海光华中西医结合医院脊柱外科, 上海 200052;上海市免疫学研究所, 上海 200025;上海光华中西医结合医院脊柱外科, 上海 200052;上海光华中西医结合医院脊柱外科, 上海 200052;上海光华中西医结合医院脊柱外科, 上海 200052;上海光华中西医结合医院脊柱外科, 上海 200052 |
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| 基金项目： | 上海市科委资助项目(编号:09411967400)~~ |
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| 摘 要： | 目的:通过建立胶原诱导性关节炎(collagen inducted arthritis,CIA)大鼠模型,评价骨碎补总黄酮在抑制CIA大鼠关节骨破坏方面的作用及机制。方法:利用皮下注射牛Ⅱ型胶原诱导Wistar大鼠发病,建立CIA大鼠模型。将造模成功且炎症分值在2分及以上的大鼠进行随机分组并进行相应治疗,评价骨碎补总黄酮对关节骨破坏情况的作用。结果:治疗12周后,骨碎补总黄酮组、骨碎补总黄酮加1/2依那西普组、依那西普组骨小梁面积百分数及骨小梁数量均明显高于灭菌用水组(P<0.05);骨小梁分离度明显小于灭菌用水组(P<0.05)。结论:骨碎补总黄酮能明显抑制CIA大鼠炎症关节骨破坏,其作用可能与骨小梁数量减少及骨小梁分离度的增大相关。
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| 关 键 词： | 关节炎 实验性 骨碎补 大鼠 中草药 |
| 收稿时间： | 2012/10/15 0:00:00 |
Experimental study on effect of Rhizoma Drynariae Flavone on bone destruction of collagen inducted arthritis rat |
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| GAO Hua-li,XIAO Lian-bo,ZHANG Zi-feng,OUYANG Gui-lin,HUANG Xin-xing,LI Ning-li,HU Jun-lin,HUANG Zhi-ming,HUANG Zheng and XIE Jun.Experimental study on effect of Rhizoma Drynariae Flavone on bone destruction of collagen inducted arthritis rat[J].China Journal of Orthopaedics and Traumatology,2013,26(9):764-767. |
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| Authors: | GAO Hua-li XIAO Lian-bo ZHANG Zi-feng OUYANG Gui-lin HUANG Xin-xing LI Ning-li HU Jun-lin HUANG Zhi-ming HUANG Zheng and XIE Jun |
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| Institution: | Department of Spinal Surgery, Guanghua Integrated Traditional and Western Medical Hospital, Shanghai 200052, China;Department of Spinal Surgery, Guanghua Integrated Traditional and Western Medical Hospital, Shanghai 200052, China;Department of Spinal Surgery, Guanghua Integrated Traditional and Western Medical Hospital, Shanghai 200052, China;Department of Spinal Surgery, Guanghua Integrated Traditional and Western Medical Hospital, Shanghai 200052, China;Department of Spinal Surgery, Guanghua Integrated Traditional and Western Medical Hospital, Shanghai 200052, China;Department of Spinal Surgery, Guanghua Integrated Traditional and Western Medical Hospital, Shanghai 200052, China;Department of Spinal Surgery, Guanghua Integrated Traditional and Western Medical Hospital, Shanghai 200052, China;Department of Spinal Surgery, Guanghua Integrated Traditional and Western Medical Hospital, Shanghai 200052, China;Department of Spinal Surgery, Guanghua Integrated Traditional and Western Medical Hospital, Shanghai 200052, China |
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| Abstract: | |
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| Keywords: | Arthritis experimental Drynaria Fortunei Rats Drugs Chinese herbal |
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