In vivo and in vitro effect of latex of Calotropis procera on gastrointestinal smooth muscles |
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Authors: | Kumar V L Shivkar Y M |
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Affiliation: | Department of Pharmacology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110029, India. kumarvl198@hotmail.com |
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Abstract: | The present study was carried out to evaluate the effect of dry latex (DL) of Calotropis procera on smooth muscles of gastrointestinal tract. Oral administration of DL to rats (50-1000 mg/kg) produced a dose-dependent decrease in intestinal transit along with a decrease in intestinal content as compared to control group. At lower doses DL produced dose-dependent contractions of gastrointestinal smooth muscles in vitro (rabbit ileum and fundus of rat stomach) that was followed by desensitization at higher doses. |
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