The oncoproteins c-erb-B2, c-fos and the tumour suppressor protein p53 in human embryos and fetuses |
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Authors: | N Miosge Wolfgang Schneider Werner G?tz and Rainer Herken |
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Institution: | (1) Zentrum Anatomie, Abteilung Histologie, Universit?t G?ttingen, Kreuzbergring 36, D-37075 G?ttingen, Germany Tel.: 0551-397050; Fax: 0551-397067, DE |
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Abstract: | Oncoproteins and tumour-suppressor proteins are thought to possess an antagonistic function in the regulation of growth and
differentiation processes during embryonic and fetal development. In contrast, in the adult, tumour growth is associated with
the overexpression of oncoproteins or the malfunction of tumour-suppressor proteins. We examined the occurrence of the tumour
proteins c-erb-B2 and c-fos and the tumour-suppressor protein p53 in 17 human embryos and fetuses with the help of immunohistochemistry.
C-erb-B2 was detected mainly in embryonic tissue that are not known for c-erb-B2-overexpression in tumours in the adult. In
contrast, c-fos was almost always located in fetal tissues corresponding to its location in adult tumours. Staining for p53
was found in a wide variety of embryonic and fetal tissues. C-erb-B2 and p53 were localized in the same tissue structures
of the developing skin, heart and muscle. In other tissues, e.g. muscle and bone, c-fos was found together with p53, suggesting
an antagonistic action of these proliferative and antiproliferative factors. Furthermore, c-erb-B2, c-fos and p53 appear to
be important for growth and differentiation processes in human development as the occurrence of these proteins was not only
restricted to specific tissues but also to specific stages of development of these tissues.
Accepted: 30 September 1996 |
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Keywords: | C-erb-B2 C-fos p53 Immunohistochemistry Human embryos and fetuses |
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