| 阿托品东莨菪碱对脑中乙酰胆碱含量的影响 |
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| 引用本文： | 卞春甫,葛晓群,郑加麟. 阿托品东莨菪碱对脑中乙酰胆碱含量的影响[J]. 徐州医学院学报, 1990, 0(4) |
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| 作者姓名： | 卞春甫 葛晓群 郑加麟 |
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| 作者单位： | 徐州医学院神经药理研究室(卞春甫，葛晓群)，徐州医学院神经药理研究室(郑加麟) |
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| 摘 要： | 放射免疫法测定大鼠脑组织中乙酰胆碱含量,大脑皮层和低位脑干分别为27.5±5.24和32.77±3.87,阿托品和东莨菪碱均可使皮层Ach含量显著下降,分别为46％和42％。低位脑干Ach含量亦有下降趋势,但经统计学处理差异无显著性。对降低原因和在生理功能中地位进行了讨论。
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| 关 键 词： | 阿托品 东莨菪碱 乙酰胆碱 放射免疫测定法 |
EFFECTS OF ATROPINE AND SCOPOLAMINE ON ACETYLC HOLINE CONTENTS IN RAT BRAIN TISSUES |
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| Bian Chunfu. EFFECTS OF ATROPINE AND SCOPOLAMINE ON ACETYLC HOLINE CONTENTS IN RAT BRAIN TISSUES[J]. Acta Academiae Medicinae Xuzhou, 1990, 0(4) |
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| Authors: | Bian Chunfu |
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| Abstract: | The Ach content was determined in different parts of rat brain by means of radioimmunoassay.In the cerebral cortex the Ach content was significantly decreased by atropine and scopolamine from 27.53+5.24 to 14.93+1.49 and 15.96+3.59 pmol/mg ( P<0.01 ) .In the lower brain stem tended to decrease too,though the change was statistically insignificant ( from 32.77+3.89 to 29.1+4.34 and 28.35+5.03 pmol/mg respectively, P>0.05). These results may be explained by the possibility that the block takes place at presynapses and results in an increased Ach release. |
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| Keywords: | atropine scopolamine acetylcholine radioimmunoassay |
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