氟西汀/氯丙咪嗪分别合并氯硝安定治疗强迫症的对比研究

目的　比较氟西汀和氯丙咪嗪分别合并氯硝安定治疗强迫症的临床疗效和副反应。方法　将合并氯硝安定治疗的 60例强迫症患者分为氟西汀组与氯丙咪嗪组 ,每组 3 0例进行对照分析。采用Yale Brown强迫量表 (Y BOCS)、副反应量表 (TESS)和临床疗效评定标准评定疗效和副反应。结果　氟西汀组与氯丙咪嗪组的疗效相似 (P >0 .0 5 ) ,两组的显效率无显著性差异 (P >0 .0 5 )。氟西汀组副反应较氯丙咪嗪组少且轻 (P <0 .0 5 )。结论　氟西汀与氯丙咪嗪合并氯硝安定治疗强迫症均有肯定疗效 ,治疗时可适当合并氯硝安定治疗。氟西汀组副反应较少 ,应首选

Comparison of fluoxetine or clomipramine combined with clonazapine in the treatment of obsessive-compulsive disorder

Objective To compare the efficacy and side effects between fluoxetine and clomipramine combined with clonazapine respectively in the treatment of obsessive-compulsive disorder(OCD). Methods 60 patients with OCD who all were given clonazapine were divided in two groups-the fluoxetine group and the clomipramine group according to the usage of different drugs. Yale-Brown Obsessive Compulsive Scale(Y-BOCS) and Treatment Emergent Scale(TESS)were used to evaluate the efficacy and the side effects.Results The efficacy of fluoxetine was similar to that of clomipramine. There was no significant difference between effective rates of these two groups (%P%>0.05). And the side effects of fluoxetine were fewer and lighter than those of clomipramine (%P%<0.05). Conclusion Both fluoxetine and clomipramine combined with clonazapine were effective in the treatment of OCD. Proper combined usage of clonazapine is beneficial to the patients. fluoxetine is better than clomipramine due to its fewer side effects.