阿卡波糖合用六味能消胶囊改善老年餐后高血糖和胰岛素敏感性的临床观察

目的 观察阿卡波糖合用六味能消胶囊降低餐后血糖、改善胰岛素敏感性的作用。方法 选择74例单纯餐后高血糖的老年患者，分为单用阿卡波糖组(对照组)37例和六味能消胶囊合用阿卡波糖组(观察组)37例，治疗1个月后分别观察两组的餐后血糖(2hPG)、血压(BP)、血脂、体重指数(BMI)以及胰岛素作用指数和不良反应等指标的变化。结果 观察组2hPG、空腹血糖(FBG)、BMI、胆固醇(CH)和低密度脂蛋白(LDL—C)较对照组改善明显(P<0．05或P<0．01)。胰岛素敏感性指数(ISI)和胰岛素抵抗计分两组均有明显改善(P<0．05或P<0．01)，且观察组与对照组比较差异有显著性(P<0．01)。观察组不良反应明显比对照组减少。结论 阿卡波糖与六味能消胶囊合用不仅可改善餐后高血糖状态，而且明显增强胰岛素敏感性，对血脂、血压、体重指数等也有明显的改善作用，两药合用后阿卡波糖的不良反应明显减少。

Clinical Observation on Improving Senile Postprandial Hyperglycemia and Insulin Sensitivity with Combination of Acarbose and Liuwei Nengxiao Capsule

To observe the effect of combination therapy of acarbose and Liuwei Nengxiao capsule (LWNXC) in improving senile postprandial hyperglycemia and insulin sensitivity. Methods Seventy-four patients with simple postprandial hyperglycemia were divided into the control group and the treated group, 37 in each group, who were treated with acarbose alone and the combination therapy respectively for 1 month, and the changes on 2 hrs postprandial glucose (2hPG), blood pressure (BP) , blood lipid, body mass index (BMI), insulin functional index as well as the adverse reaction of acarbose in the two groups were observed. Results After treatment, the levels of 2hPG, fasting blood glucose (FBG), BMI, total cholesterol and lowdensity lipoprotein-cholesterol were improved in the treated groups more significantly than those in the control group (P<0.05 or P<0.01). Insulin sensitive index (ISI) and insulin resistance were improved in the two group (P<0.05 or P<0.01), but the improvement in the treated group was more significant than that in the control group (P<0.01). Moreover, the adverse reactions were less in the treated group than in the control group. Conclusion The combination therapy of acarbose and LWNXC could not only improve the postprandial hyperglycemia , but also markedly increase the insulin sensitivity, and shows obvious improving effect on parameters of blood lipid, BP and BMI. The adverse reaction could be evidently reduced by combined use with LWNXC.