| 人胃粘膜上皮细胞DNA修复能力与胃癌高患病率研究 |
| |
| 引用本文： | 吴德丰,郑志竑,张翼,柳惠玲. 人胃粘膜上皮细胞DNA修复能力与胃癌高患病率研究[J]. 肿瘤防治研究, 1988, 15(2): 60-62 |
| |
| 作者姓名： | 吴德丰 郑志竑 张翼 柳惠玲 |
| |
| 作者单位： | 福建医学院肿瘤研究室 |
| |
| 摘 要： | 本工作以体外短期培养的人胃粘膜上皮细胞为材料,采用羟灰石柱层析及液体闪烁计数的方法,分析了49例福建省胃癌高发区及17例胃癌低发区人群胃粘膜上皮细胞DNA修复能力,发现胃癌高发区人群组胃粘膜上皮细胞DNA修复能力显著低于低发区人群组。
|
| 关 键 词： | 胃癌高发区 胃癌低发区 胃粘膜上皮细胞 体外培养UDS(非周期DNA合成)DNA修复 羟基磷灰石柱层析 液体闪烁计数 |
ABILITY IN AND STUDY OF DNA REPAIR HUMAN GASTRIC MUCOSAL EPITHELIAL CELLS HIGH GASTRIC CANCER MORTALITY IN FU JIAN PROVINCE |
| |
| Wu Defeng. ABILITY IN AND STUDY OF DNA REPAIR HUMAN GASTRIC MUCOSAL EPITHELIAL CELLS HIGH GASTRIC CANCER MORTALITY IN FU JIAN PROVINCE[J]. Cancer Research on Prevention and Treatment, 1988, 15(2): 60-62 |
| |
| Authors: | Wu Defeng |
| |
| Affiliation: | Department of Tumor Research, Fujian Medical College |
| |
| Abstract: | Isolated mucosal epithelial cells derived front with gastric cancer from high and low incidence surgically resected human stomach areas in Fujian studied. Following maintenance in short-term culture in vitro, the province were mucosal tissue was exposed to ultraviolet for 25 minutes and then cultured in the presence TdR and hydrourea, The unscheduled DNA synthesis (UDS) was assessed by of(aH) using hydrosylapatite the cpm/ug DNA column chromatograph and liquid scintillation was In present study, determined the DNA as an indirect measure repair ability in gastric of DNA mucosal counting set, and damage repair. cells in high inci- dence This area group is significantly lower than that in low may play part of the role in the inducing of gastric incidence area group, cancer |
| |
| Keywords: | |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《肿瘤防治研究》浏览原始摘要信息 |
|
点击此处可从《肿瘤防治研究》下载免费的PDF全文 |
|
