YY1 在胰岛素瘤中的表达及意义

目的探讨YY1在良、恶性胰岛素瘤组织中的表达情况及意义。方法收集2000~2014年南方医院19例胰腺神经内分泌 肿瘤组织蜡块，利用免疫组化法检测19例标本中YY1的蛋白表达水平。结果YY1在良恶性胰岛素瘤中组织中都有表达，恶性 胰岛素瘤组织中YY1表达强度高于良性胰岛素瘤组织（P=0.042），YY1表达强度与胰岛素瘤的良恶性质存在正相关关系（P= 0.037），YY1表达强度高的胰岛素瘤更具恶性潜能。结论YY1的高表达强度与胰岛素瘤发生发展有一定关系，YY1有望成为 检测胰岛素瘤恶性转化的新肿瘤标志物。

Expression of YY 1 protein in human insulinoma and its clinical implication

Objective To investigate the expression of Yin Yang 1 (YY1) protein in human insulinoma and explore its clinical significance. Methods Nineteen pancreatic neuroendocrine tumor tissue were collected from patients treated in Nanfang Hospital between 2000 and 2014. The protein expression of YY1 in benign and malignant insulinoma tissues were detected by immunohistochemistry. Results Positive expression for YY1 protein was detected in both benign and malignant tumor tissues, but the malignant tissues had a significantly greater intensity of YY1 expression than the benign tissues (P=0.042). The intensity of YY1 expression was positively correlated with the nature of the tumor, and the insulinomas with high expressions of YY1 had significantly greater malignant potentials (P=0.037). Conclusion The high expression of YY1 protein is associated with the development of insulinima. YY1 may serve as a new tumor marker for detecting the malignant transformation of insulinoma.