Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage |
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| Authors: | Joanne M. Bowen Rachel J. Gibson Adrian G. Cummins Dorothy M. K. Keefe |
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| Affiliation: | (1) Department of Medical Oncology, Royal Adelaide Hospital, North Terrace, Adelaide, 5000, South Australia, Australia;(2) Department of Medicine, University of Adelaide, Adelaide, South Australia, Australia;(3) Department of Gastroenterology and Hepatology, The Queen Elizabeth Hospital, Adelaide, South Australia, Australia |
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| Abstract: | Intestinal mucositis occurs as a consequence of cytotoxic treatment through multiple mechanisms including induction of crypt cell death (apoptosis) and cytostasis. The molecular control of these actions throughout the gastrointestinal tract has yet to be fully elucidated; however, they are known to involve p53, the Bcl-2 family and caspases. This review will provide an overview of current research as well as identify areas where gaps in knowledge exist. |
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| Keywords: | Mucositis p53 Bcl-2 family caspases |
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